{
  "abstract": "Background: Electroacupuncture (EA) reshapes intestinal flora; whether post‐EA fecal microbiota transplantation (post‐EA FMT) regulates gastrointestinal hormones via the gut microbiota–bile acid (BA) pathway remains unclear.\n\nMethods: Sham EA (SEA) served as control. Gastrointestinal hormones/motility were assessed post‐EA. Fecal microbiota from EA/SEA‐treated rats were transplanted into pseudo‐germ‐free (PGF) rats. Gut microbiota and BA profiles were analyzed.\n\nResults: EA downregulated Ghrelin, PYY, GLP‐1, upregulated CCK, and enhanced motility in FD rats. Post‐EA FMT increased Firmicutes/Bacteroidetes (phylum); upregulated Lactobacillus, Prevotella, [Prevotella] (genus); decreased Blautia, Proteobacteria, Bacteroides; reduced multiple BAs (including TUDCA/TCDCA). TUDCA/TCDCA showed strong positive correlation.\n\nConclusions: The gut microbiota‐BA pathway associates with post‐EA FMT's beneficial regulation of gastrointestinal hormones. The gut microbiota–BA pathway is associated with post‐EA FMT's beneficial regulation of gastrointestinal hormones. The gut microbiota–BA pathway is associated with post‐EA FMT's beneficial regulation of gastrointestinal hormones. The Lactobacillus/TUDCA/TCDCA axis represents a candidate pathway that may contribute to this process (validation pending). Current findings indicate strong correlations, not causality.",
  "abstract_shown": true,
  "affiliations": [
    "Acupuncture Department The First Affiliated Hospital of Henan University of CM Zhengzhou Henan Province China",
    "Department of Hepatology and Gastroenterology The First Affiliated Hospital of Henan University of CM Zhengzhou Henan Province China",
    "College of Life Sciences Shanghai Normal University Shanghai China",
    "Institute of Acupuncture and Tuina Henan University of Chinese Medicine Zhengzhou Henan Province China",
    "Department of Spleen and Stomach The Second Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing Jiangsu Province China",
    "Department of Radiology Henan Provincial People's Hospital and Zhengzhou University People's Hospital and Henan Provincial Key Laboratory of Neurological Disease Imaging Diagnosis and Research Zhengzhou Henan Province China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yong‐Li Han",
      "orcid": "0000-0001-9673-9181"
    },
    {
      "affs": [
        1
      ],
      "name": "Dong‐Fang Shang"
    },
    {
      "affs": [
        2
      ],
      "name": "Juli Tang"
    },
    {
      "affs": [
        3
      ],
      "name": "Dong‐Dong Yu",
      "orcid": "0009-0002-8686-7758"
    },
    {
      "affs": [
        4
      ],
      "name": "Liang‐Yu Zhang",
      "orcid": "0000-0001-9895-0263"
    },
    {
      "affs": [
        5
      ],
      "name": "Jing Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Qing‐Bo Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1rzxks13rxn15.bib",
  "cited_by": 0,
  "doi": "10.1111/jgh.70744",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13731036/",
  "id": "1rzxks13rxn15",
  "issns": [
    "0815-9319",
    "1440-1746"
  ],
  "landing_url": "https://doi.org/10.1111/jgh.70744",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article ‐ Gastroenterology (Experimental)"
    ],
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7213226305",
  "pdf_url": null,
  "pmcid": "PMC13731036",
  "pmid": "42745194",
  "published": "2026-09-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1rzxks13rxn15.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:21:18Z",
      "native_id": "PMC13731036",
      "source": "pmc",
      "url": "https://doi.org/10.1111/jgh.70744"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Gut microbiota and health",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Postelectroacupuncture Fecal Microbiota Transplantation (post‐EA FMT) Regulates Gastrointestinal Hormones in Functional Dyspepsia Rats Is Associated With Modulation of the Intestinal Microbiota‐Bile Acid Metabolic Pathway",
  "title_text": "Postelectroacupuncture Fecal Microbiota Transplantation (post‐EA FMT) Regulates Gastrointestinal Hormones in Functional Dyspepsia Rats Is Associated With Modulation of the Intestinal Microbiota‐Bile Acid Metabolic Pathway",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:18Z",
  "url": "https://research.draconitic.com/paper/1rzxks13rxn15",
  "venue": "Journal of Gastroenterology and Hepatology",
  "versions": []
}