{
  "abstract": "Introduction\n\nShrinking lung syndrome (SLS) is a rare complication of systemic lupus erythematosus. It is characterized by dyspnoea and a restrictive ventilatory defect, often associated with pleuritic chest pain. Given its rarity, there is no standardized treatment. Most published case reports describe a favourable outcome with corticosteroids alone or in combination with other immunosuppressive agents, such as cyclophosphamide or rituximab. Only a few cases treated with belimumab have been reported.Case description\n\nWe present the case of a 16-year-old female presenting with pleuritic chest pain, orthopnoea, and a restrictive ventilatory defect. Further investigations revealed positive antinuclear antibodies, a small left pleural effusion, and mild elevation of the left hemidiaphragm, findings consistent with SLS. Treatment with corticosteroids and belimumab was initiated, leading to significant clinical and biological improvement.Conclusion\n\nThis case highlights the potential role of belimumab as a first-line treatment for SLS in combination with corticosteroids alone.Learning points\n\nShrinking lung syndrome is a rare condition with no standardized treatment.Most reported cases describe the use of corticosteroids in combination with azathioprine, mycophenolate mofetil or rituximab. Only a few cases have reported the use of belimumab.Belimumab may be considered as a first-line treatment option which could induce remission.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pneumology, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.",
    "Department of Immuno-Allergology, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Rémy Père"
    },
    {
      "affs": [
        1
      ],
      "name": "Anouk Le Goueff"
    },
    {
      "affs": [
        0
      ],
      "name": "Marina Nguenang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1s4xez64jwsxf.bib",
  "cited_by": 0,
  "doi": "10.12890/2026_007315",
  "fulltext_url": "https://europepmc.org/articles/PMC13750781",
  "id": "1s4xez64jwsxf",
  "issns": [
    "2284-2594"
  ],
  "landing_url": "https://europepmc.org/article/MED/43012020",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2745|Systemic Lupus Erythematosus Research"
    ]
  ],
  "openalex": "W7222461631",
  "pdf_url": "https://europepmc.org/articles/PMC13750781?pdf=render",
  "pmcid": "PMC13750781",
  "pmid": "43012020",
  "published": "2026-10-16",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1s4xez64jwsxf.ris",
  "sources": [
    {
      "first_seen": "2026-11-12T15:25:13Z",
      "native_id": "MED:43012020",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/43012020"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2745|Systemic Lupus Erythematosus Research",
      "subfield": "general"
    }
  ],
  "title": "Shrinking Lung Syndrome with Favourable Response to Belimumab and Corticosteroids Alone.",
  "title_text": "Shrinking Lung Syndrome with Favourable Response to Belimumab and Corticosteroids Alone.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T15:20:22Z",
  "url": "https://research.draconitic.com/paper/1s4xez64jwsxf",
  "venue": "European journal of case reports in internal medicine",
  "versions": []
}