{
  "abstract": "Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) is the most common genetic subgroup in adult ALL, and its incidence increases with age. In this longitudinal single-subject study, we investigate erythrocyte deformability as a disease-associated biomechanical marker in parallel with clinical, hematological, and molecular response throughout the treatment process in a 75-year-old patient diagnosed with Ph+ ALL. Using optical tweezers, we performed high-resolution single-cell mechanical stretching experiments to quantify the deformability of individual RBCs obtained from the patient and a healthy control. Our measurements reveal a pronounced relation between state of diseases/therapy and RBC deformability in the ALL patient, indicating systemic alterations in cellular biomechanics associated with leukemic pathophysiology. These findings suggest that changes in RBC mechanical properties, probed through non-invasive optical tweezers-based techniques, may accompany disease presence and progression.",
  "abstract_shown": true,
  "affiliations": [
    "Istanbul Medipol University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "T. Pesen"
    },
    {
      "name": "Y. Koc"
    },
    {
      "name": "B. B. Bagislar"
    },
    {
      "name": "N. Alhan"
    },
    {
      "name": "B. Akgun"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1sbfhprnc6t26.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.29.762767",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.29.762767v1.full",
  "id": "1sbfhprnc6t26",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.29.762767v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "biophysics"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.29.762767v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1sbfhprnc6t26.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:21:22Z",
      "native_id": "10.64898/2026.10.29.762767",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.29.762767v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "biorxiv:biophysics",
      "subfield": "biophysics"
    }
  ],
  "title": "RBC Deformability During Acute Lymphoblastic Leukemia Treatment",
  "title_text": "RBC Deformability During Acute Lymphoblastic Leukemia Treatment",
  "type": "preprint",
  "updated_at": "2026-11-01T00:21:16Z",
  "url": "https://research.draconitic.com/paper/1sbfhprnc6t26",
  "venue": "bioRxiv",
  "versions": []
}