{
  "abstract": "Corni Fructus (CF), a medicinal and edible herb, is characterized by sour and astringent properties in both taste and the Traditional Chinese Medicine Five-Flavor Theory. However, the chemical basis of these sensory attributes remains unclear. This study integrated UPLC-MS/MS profiling, electronic tongue analysis, human sensory evaluation, and molecular docking to identify sour/astringent components and explore their sensory relevance. A total of 82 features were characterized, including 52 organic acids, 28 tannin-related features, and 2 unclassified features. Sensory and E-tongue analyses revealed region-dependent differences in sourness, astringency, and bitterness. Correlation analysis and PLSR suggested malic acid and related derivatives may contribute to sourness, whereas galloylated tannins, including 3-O-galloyl-d-glucose, were associated with astringency- and bitterness-related responses. Molecular docking provided preliminary support for interactions between compounds and taste-related protein models. These findings provide candidate markers for flavor-oriented quality evaluation of CF and offer a foundation for sensory validation and medicinal-edible product development.",
  "abstract_shown": true,
  "affiliations": [
    "Henan Collaborative Innovation Center for Research and Development on the Whole Industry Chain of Yu-Yao, Henan University of Chinese Medicine, Zhengzhou 450046, China.",
    "Engineering Technology Research Center for Comprehensive Development and Utilization of Authentic Medicinal Materials in Henan Province, Zhengzhou 450046, China.",
    "Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yadi Hou"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hui Guo"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yalin Liu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yixiao Li"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Manliang Chen"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Haiyang Du"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jun Chi"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Zhimin Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Liping Dai"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1sf19rt3byex7.bib",
  "cited_by": 0,
  "doi": "10.1016/j.fochx.2026.104564",
  "fulltext_url": "https://europepmc.org/articles/PMC13682183",
  "id": "1sf19rt3byex7",
  "issns": [
    "2590-1575"
  ],
  "landing_url": "https://europepmc.org/article/MED/42903686",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2707|Traditional Chinese Medicine Analysis"
    ]
  ],
  "openalex": "W7221099409",
  "pdf_url": "https://europepmc.org/articles/PMC13682183?pdf=render",
  "pmcid": "PMC13682183",
  "pmid": "42903686",
  "published": "2026-10-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1sf19rt3byex7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42903686",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42903686"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2707|Traditional Chinese Medicine Analysis",
      "subfield": "general"
    }
  ],
  "title": "Candidate compounds associated with sourness and astringency in Corni Fructus: an integrated analysis of chemical profiles, sensory evaluation, and molecular docking.",
  "title_text": "Candidate compounds associated with sourness and astringency in Corni Fructus: an integrated analysis of chemical profiles, sensory evaluation, and molecular docking.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/1sf19rt3byex7",
  "venue": "Food chemistry: X",
  "versions": []
}