{
  "abstract": "Evidence supporting the efficacy and safety of [177Lu]Lu-DOTATATE in refractory meningiomas derives mainly from small, single-center studies. The French national multicenter MELUTE study aimed to consolidate these data using a standardized regimen within a compassionate-use program approved by a national multidisciplinary tumor board. Methods: In this retrospective multicenter cohort study, patients with refractory meningiomas treated with [177Lu]Lu-DOTATATE in 18 French centers between July 2022 and December 2024 were included. Treatment consisted of 7.4 GBq every 8 wk for up to 4 cycles. Clinical data (demographics, histologic World Health Organization grade [WHO], prior treatments, number of cycles, toxicity, progression, survival status as of October 1, 2025) were collected. Baseline [68Ga]Ga-DOTATOC PET and brain MRI scans obtained before and after treatment were centrally reviewed. The primary endpoint was 6-mo progression-free survival (PFS) assessed using volumetric Response Assessment in Neuro-Oncology Group criteria. Secondary endpoints were PFS, overall survival (OS), and safety. Results: Sixty-nine patients were included (mean age, 65.1 ± 13.2 y; 52% female): 13 WHO grade 1, 42 WHO grade 2, 8 WHO grade 3, and 6 without histology. Most had prior surgery (86%) or radiotherapy (93%); 32% received prior systemic therapy. Twelve patients (17%) did not complete 4 cycles; only one discontinuation was toxicity-related. Six-month PFS was 70% (95% CI, 58.7-80.4%). Median PFS was 14.6 mo (95% CI, 13.3-18.5 mo), and median OS was 27.6 mo (95% CI, 24.2 mo to not reached). Grade 3 adverse events, mainly lymphopenia, occurred in 16%. Meningioma WHO grade independently predicted PFS, whereas higher Karnofsky performance status and corticosteroid use were protective; worse OS was associated with higher baseline tumor growth rate and prior systemic therapy. Conclusion: MELUTE demonstrates promising efficacy and favorable safety of [177Lu]Lu-DOTATATE in refractory meningiomas with limited therapeutic options.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 45,
  "authors": [
    {
      "name": "Nicolas Garabedian"
    },
    {
      "name": "Timothée Zaragori"
    },
    {
      "name": "Emeline Tabouret"
    },
    {
      "name": "Luc Taillandier"
    },
    {
      "name": "Catherine Ansquer"
    },
    {
      "name": "Edouard Samarut"
    },
    {
      "name": "Sarah Boughdad"
    },
    {
      "name": "Marc Sanson"
    },
    {
      "name": "Caroline Bund"
    },
    {
      "name": "Georges-Noël Lambert"
    },
    {
      "name": "Catherine Cheze Le Rest"
    },
    {
      "name": "Anthony Joncour"
    },
    {
      "name": "Jacques Darcourt"
    },
    {
      "name": "Marie Onno"
    },
    {
      "name": "Gauthier Delaby"
    },
    {
      "name": "Enora Vauléon"
    },
    {
      "name": "Inna Dygai-Cochet,"
    },
    {
      "name": "François Ghiringhelli"
    },
    {
      "name": "Emmanuel Deshayes"
    },
    {
      "name": "Julien Boetto"
    },
    {
      "name": "Agathe Edet-Sanson"
    },
    {
      "name": "Adrien Carle-Ortiz"
    },
    {
      "name": "Anthime Flaus"
    },
    {
      "name": "François Ducray"
    },
    {
      "name": "Thibault Fidani"
    },
    {
      "name": "Jean-Sébastien Guillamo"
    },
    {
      "name": "Tatiana Horowitz"
    },
    {
      "name": "Pierre Meneret"
    },
    {
      "name": "Elodie Vauléon"
    },
    {
      "name": "Elske Quak"
    },
    {
      "name": "Jeanne Riverain"
    },
    {
      "name": "Solene Querellou"
    },
    {
      "name": "Vincent Bourbonne"
    },
    {
      "name": "Ghoufrane Tlili"
    },
    {
      "name": "Aymeri Huchet"
    },
    {
      "name": "Lavinia Vija"
    },
    {
      "name": "Justine Attal"
    },
    {
      "name": "Gabriela Hossu"
    },
    {
      "name": "Laëtitia Imbert"
    },
    {
      "name": "Betty Salgues"
    },
    {
      "name": "Éric Guedj"
    },
    {
      "name": "Matthieu Peyre"
    },
    {
      "name": "Thomas Graillon"
    },
    {
      "name": "Caroline Boursier"
    },
    {
      "name": "Antoine Verger"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1snkg6sp8wb9f.bib",
  "cited_by": 0,
  "doi": "10.2967/jnumed.126.272735",
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  "id": "1snkg6sp8wb9f",
  "issns": [
    "0161-5505",
    "1535-5667"
  ],
  "landing_url": "https://hal.science/hal-05830001v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "openalex",
      "2713|Meningioma and schwannoma management"
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  "pdf_url": "https://hal.science/hal-05830001/document",
  "pmcid": null,
  "pmid": "42880958",
  "published": "2026-10-21",
  "publisher": "Society of Nuclear Medicine",
  "ris": "https://research.draconitic.com/paper/1snkg6sp8wb9f.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:00Z",
      "native_id": "hal-05830001",
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  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.scco.neur",
      "subfield": "neuroscience"
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    {
      "field": "biology",
      "origin": "hal:1.sdv.ib",
      "subfield": "systems-synthetic"
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    {
      "field": "medicine",
      "origin": "hal:1.sdv.mhep",
      "subfield": "general"
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  ],
  "title": "Radiopharmaceutical Therapy with [ 177 Lu]Lu-DOTATATE in Refractory Meningiomas: Results from the French Multicenter MELUTE Cohort",
  "title_text": "Radiopharmaceutical Therapy with [ 177 Lu]Lu-DOTATATE in Refractory Meningiomas: Results from the French Multicenter MELUTE Cohort",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:00Z",
  "url": "https://research.draconitic.com/paper/1snkg6sp8wb9f",
  "venue": "Journal of Nuclear Medicine",
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