{
  "abstract": "This work studies the synthesis of complexes using chlorambucil (La-CLA) as a ligand and lanthanum as a metallic center, in order to enhance their biological activities. The compounds produced were characterized by infrared spectroscopy and 13C and 1H nuclear magnetic resonance; the results obtained indicate that coordination bonds formed between the ligands and that La3+ was present in a bidentate way through carboxylic groups in the complexes. Elemental and thermogravimetric analyses indicate that the stoichiometry obtained for chlorambucil complexes was a 2:1 ligand:metal ratio. The anticancer activity assays indicated that the La-CLA complex showed better activity than the ligands against the cell lines K562 (Chronic Myeloid Leukemia), HT-29 (Colorectal Cancer), Caco 2 (Human Colorectal Adenocarcinoma) and B16-F10 (Murine Melanoma), with GI50 values in the range of 0.31–31.86 μM. The La-CLA complex showed a selectivity index (SI) equal to 15.64 for the K562 cell line with respect to normal J774 cells (murine macrophages).",
  "abstract_shown": true,
  "affiliations": [
    "Chemistry Institute, Federal University of Mato Grosso do Sul, Campo Grande 79079-900, MS, Brazil",
    "Faculty of Pharmacy, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande 79079-900, MS, Brazil"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Fernanda Timoteo"
    },
    {
      "affs": [
        0
      ],
      "name": "Kristiane Fanti Del Pino",
      "orcid": "0000-0003-2162-5483"
    },
    {
      "affs": [
        1
      ],
      "name": "Danielle Bogo",
      "orcid": "0000-0003-0233-3047"
    },
    {
      "affs": [
        0
      ],
      "name": "Vasilii Khripun",
      "orcid": "0000-0003-0833-3048"
    },
    {
      "affs": [
        0
      ],
      "name": "Franciele Garcia Baveloni",
      "orcid": "0000-0002-9021-5245"
    },
    {
      "affs": [
        0
      ],
      "name": "Sabrina Epifânio Soares de Souza"
    },
    {
      "affs": [
        0
      ],
      "name": "Brunna Mercedes Barboza Borges",
      "orcid": "0009-0008-3145-4474"
    },
    {
      "affs": [
        0
      ],
      "name": "Guilherme Pereira Biazoto"
    },
    {
      "affs": [
        0
      ],
      "name": "Diego Boldo",
      "orcid": "0009-0004-5073-4632"
    },
    {
      "affs": [
        0
      ],
      "name": "Adriana Pereira Duarte",
      "orcid": "0000-0002-0335-8898"
    },
    {
      "affs": [
        0
      ],
      "name": "Adriana da Silva Posso"
    },
    {
      "affs": [
        0
      ],
      "name": "Marco Antonio Utrera Martines",
      "orcid": "0000-0003-0405-6514"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1sw2v8dga4y5e.bib",
  "cited_by": 0,
  "doi": "10.3390/molecules31203584",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13707427/?tool=EBI",
  "id": "1sw2v8dga4y5e",
  "issns": [
    "1420-3049"
  ],
  "landing_url": "https://www.mdpi.com/1420-3049/31/20/3584",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Metal complexes synthesis and properties"
    ]
  ],
  "openalex": "W7221147069",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13707427/pdf/?tool=EBI",
  "pmcid": "PMC13707427",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/1sw2v8dga4y5e.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:42Z",
      "native_id": "10.3390/molecules31203584",
      "source": "crossref",
      "url": "https://www.mdpi.com/1420-3049/31/20/3584"
    },
    {
      "first_seen": "2026-10-30T12:21:44Z",
      "native_id": "PMC:PMC13707427",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13707427"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Metal complexes synthesis and properties",
      "subfield": "oncology"
    }
  ],
  "title": "Synthesis, Characterization and In Vitro Cytotoxic Assay of La(III) Complex with Chlorambucil",
  "title_text": "Synthesis, Characterization and In Vitro Cytotoxic Assay of La(III) Complex with Chlorambucil",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:44Z",
  "url": "https://research.draconitic.com/paper/1sw2v8dga4y5e",
  "venue": "Molecules",
  "versions": []
}