{
  "abstract": "Transplantation is limited by how long organs survive outside the body. Existing preservation methods slow metabolism or sustain physiological support, but neither eliminates ischemia-reperfusion injury (IRI), which shortens storage and drives organ discard. Embryonic diapause and hibernation show that mammalian cells retain a latent capacity for reversible metabolic arrest. Screening the PI3K-mTOR axis, we identified a dual inhibitor that pauses embryonic stem cells reversibly at ambient oxygen and holds intact mouse embryos in arrest for 11 days. Combined with a mitochondria-targeted hydrogen sulfide donor, this yields TorPause: a two-component flush pairing metabolic pausing with mitochondrial protection, compatible with existing preservation protocols. In a rat liver transplantation model, TorPause reduced structural injury and improved recipient survival after severe warm ischemic storage, potentially expanding the usable donor pool.",
  "abstract_shown": true,
  "affiliations": [
    "ISCBRM, Stanford University School of Medicine"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "J. Bhadury"
    },
    {
      "name": "T. Tajima"
    },
    {
      "name": "F. P. Suchy"
    },
    {
      "name": "H. Masaki"
    },
    {
      "name": "J. Zhang"
    },
    {
      "name": "M. Rivera"
    },
    {
      "name": "T. Nishimura"
    },
    {
      "name": "C. T. Charlesworth"
    },
    {
      "name": "C. O. Esquivel"
    },
    {
      "name": "H. Nakauchi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1sxqnn1r1s9ke.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.08.755167",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.08.755167v1.full",
  "id": "1sxqnn1r1s9ke",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.08.755167v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "developmental biology"
    ],
    [
      "openalex",
      "2746|Organ Transplantation Techniques and Outcomes"
    ]
  ],
  "openalex": "W7221195090",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.08.755167v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1sxqnn1r1s9ke.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:26:52Z",
      "native_id": "10.64898/2026.10.08.755167",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.08.755167v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:developmental biology",
      "subfield": "developmental-biology"
    }
  ],
  "title": "TorPause: Efficient Static Organ Preservation for Transplants",
  "title_text": "TorPause: Efficient Static Organ Preservation for Transplants",
  "type": "preprint",
  "updated_at": "2026-10-30T12:26:52Z",
  "url": "https://research.draconitic.com/paper/1sxqnn1r1s9ke",
  "venue": "bioRxiv",
  "versions": []
}