{
  "abstract": "Background\n\nLight chain (AL) amyloidosis is typically associated with plasma cell dyscrasias but can rarely arise from low-grade B-cell non-Hodgkin lymphoma. Renal involvement may present with nephrotic-range proteinuria, acute kidney injury, edema, anasarca, and hypoalbuminemia. Recognizing lymphoma-associated AL amyloidosis is essential because diagnosis requires tissue confirmation, and treatment must target the underlying clonal B-cell disorder.Case\n\nWe report a rare case of severe renal AL amyloidosis in a patient with known low-grade B-cell non-Hodgkin lymphoma previously treated with rituximab. The patient presented with witnessed syncope, progressive peripheral edema, anasarca, and hypotension. Initial evaluation showed acute kidney injury with nephrotic-range proteinuria, including a urine protein-to-creatinine ratio greater than 10 g/g. Workup for autoimmune, infectious, and malignant causes of proteinuric kidney disease revealed positive hepatitis C antibody, mildly elevated serum lambda free light chains, a mildly decreased kappa-to-lambda ratio, and serum immunofixation positive for an IgM monoclonal lambda gammopathy. Renal biopsy demonstrated severe AL amyloidosis with predominant renal involvement. Bone marrow biopsy showed low-grade B-cell non-Hodgkin lymphoma involving 85% of the marrow, with CD20-positive immunophenotyping.Conclusion\n\nThis case highlights a rare presentation of renal AL amyloidosis secondary to low-grade B-cell non-Hodgkin lymphoma. Persistent nephrotic-range proteinuria in patients with B-cell lymphoma, particularly with IgM lambda monoclonal gammopathy, should prompt evaluation for amyloidosis with renal biopsy and hematologic assessment.",
  "abstract_shown": true,
  "affiliations": [
    "Graduate Medical Education (GME), Hospital Corporation of America (HCA) Blake Florida Hospital, Bradenton, FL, United States.",
    "NEPHROCOR, Bradenton, FL, United States.",
    "Manatee Kidney Diseases Consultants, Bradenton, FL, United States."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Alex Matthaeus"
    },
    {
      "affs": [
        1
      ],
      "name": "David Thomas"
    },
    {
      "affs": [
        2
      ],
      "name": "Hakan R Toka"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1t0cw0jen3cm0.bib",
  "cited_by": 0,
  "doi": "10.3389/fneph.2026.1959759",
  "fulltext_url": "https://europepmc.org/articles/PMC13680236",
  "id": "1t0cw0jen3cm0",
  "issns": [
    "2813-0626"
  ],
  "landing_url": "https://europepmc.org/article/MED/42903237",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Amyloidosis: Diagnosis, Treatment, Outcomes"
    ]
  ],
  "openalex": "W7220677653",
  "pdf_url": "https://europepmc.org/articles/PMC13680236?pdf=render",
  "pmcid": "PMC13680236",
  "pmid": "42903237",
  "published": "2026-10-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1t0cw0jen3cm0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:57Z",
      "native_id": "MED:42903237",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42903237"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Amyloidosis: Diagnosis, Treatment, Outcomes",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Case Report: Light chain amyloidosis in a patient with low-grade B-cell lymphoma.",
  "title_text": "Case Report: Light chain amyloidosis in a patient with low-grade B-cell lymphoma.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:57Z",
  "url": "https://research.draconitic.com/paper/1t0cw0jen3cm0",
  "venue": "Frontiers in nephrology",
  "versions": []
}