{
  "abstract": "Background: Progressive multifocal leukoencephalopathy (PML) is a rare fatal central nervous system demyelinating disease caused by John Cunningham virus (JCV). Immunodeficiency induces JCV reactivation, resulting in oligodendrocyte lysis, demyelination, and astrocytic dysfunction.\n\nCase presentation: We reported a 54-year-old male presenting with mild motor aphasia and cognitive decline. He was initially misdiagnosed with cirrhotic hepatic encephalopathy, with no response to ammonia-lowering treatment. Routine cerebrospinal fluid tests were unremarkable, while Matagenomics Capture (MetaCAP), a high-throughput sequencing technology identified 226 JCV sequences, confirming PML.\n\nConclusion: PML has heterogeneous manifestations and is easily underdiagnosed in cirrhotic patients. Early differential diagnosis, CSF JCV detection, or brain biopsy is essential.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, The Third Affiliated Hospital of Naval Military Medical University, Shanghai, China",
    "Department of Neurology, The First Affiliated Hospital of Naval Military Medical University, Shanghai, China"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Chenrui Song"
    },
    {
      "affs": [
        1
      ],
      "name": "Yanqun Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiaoying Bi"
    },
    {
      "affs": [
        0
      ],
      "name": "Shi Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1ta8wxhr4g8r7.bib",
  "cited_by": 0,
  "doi": "10.1186/s12883-026-05154-3",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13741553/",
  "id": "1ta8wxhr4g8r7",
  "issns": [
    "1471-2377"
  ],
  "landing_url": "https://doi.org/10.1186/s12883-026-05154-3",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "openalex",
      "2730|Polyomavirus and related diseases"
    ]
  ],
  "openalex": "W7171849370",
  "pdf_url": null,
  "pmcid": "PMC13741553",
  "pmid": "42989120",
  "published": "2026-07-31",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/1ta8wxhr4g8r7.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T12:22:35Z",
      "native_id": "PMC13741553",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12883-026-05154-3"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Polyomavirus and related diseases",
      "subfield": "oncology"
    }
  ],
  "title": "A case of progressive multifocal leukoencephalopathy in a cirrhotic patient",
  "title_text": "A case of progressive multifocal leukoencephalopathy in a cirrhotic patient",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T12:22:35Z",
  "url": "https://research.draconitic.com/paper/1ta8wxhr4g8r7",
  "venue": "BMC Neurology",
  "versions": []
}