{
  "abstract": "An inorganic–organic hybrid nanomaterial, Cu@MCMCal, was synthesized by immobilizing p-tert-butyl calix[4]arene on to mesoporous silica followed by incorporation of CuNPs. The synthesized nanomaterial was characterized extensively using various analytical techniques such as FT-IR, UV–Vis spectroscopy, TEM, PXRD, XPS, Cu LMM Auger, BET, and TGA analyses. The hybrid nanomaterial was evaluated for its catalytic performance toward peroxidase-like activity using 3,3′,5,5′-tetramethylbenzidine (TMB) and o-phenylenediamine (OPD) as a substrate at room temperature at pH 4.5 in acetate buffer and pH 7.4 in PBS buffer, respectively. Enzyme kinetics was performed for both the substrates using the Michaelis–Menten steady-state kinetics and the Lineweaver–Burk plot to determine the catalytic affinity. Based on the kinetic measurements, the values of the Km for TMB and OPD were found to be 0.661 ± 0.143 and 0.606 ± 0.061 mM, respectively. The hybrid nanoenzyme also exhibits the oxidase-like activity using dopamine as a substrate at pH 7.4 in PBS buffer. The Cu@MCMCal nanomaterial acted as a nanoenzyme, efficient for catalysis toward oxidation reactions with better cost effectiveness and improved stability and recyclability as compared to biological enzymes. Therefore, a promising, stable, efficient, and robust nanoenzyme has been development for oxidation reactions.",
  "abstract_shown": true,
  "affiliations": [
    "J.C. Bose University of Science and Technology, YMCA , , , ,",
    "Indian Institute of Technology Bombay , , , ,",
    "University of Virginia , , , ,"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Meenakshi Goyal"
    },
    {
      "affs": [
        1
      ],
      "name": "Anuj Kumar"
    },
    {
      "affs": [
        2
      ],
      "name": "Pardeep Kumar"
    },
    {
      "affs": [
        0
      ],
      "name": "Bhawna Uttam",
      "orcid": "0000-0002-7031-318X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1teaveq22xa39.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.6c07489",
  "fulltext_url": null,
  "id": "1teaveq22xa39",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c07489/5453036/Development-of-Supramolecular-Calix-4-arene-MCM",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2505|Advanced Nanomaterials in Catalysis"
    ]
  ],
  "openalex": "W7222535754",
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/acsomega.6c07489",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-16",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/1teaveq22xa39.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:39Z",
      "native_id": "10.1021/acsomega.6c07489",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c07489/5453036/Development-of-Supramolecular-Calix-4-arene-MCM"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2505|Advanced Nanomaterials in Catalysis",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Development of Supramolecular Calix[4]arene-MCM-Based Nanomaterials Doped with CuNPs: An Inorganic–Organic Hybrid Recyclable Nanoenzyme as a Potent Peroxidase and Oxidase Mimic",
  "title_text": "Development of Supramolecular Calix[4]arene-MCM-Based Nanomaterials Doped with CuNPs: An Inorganic–Organic Hybrid Recyclable Nanoenzyme as a Potent Peroxidase and Oxidase Mimic",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:39Z",
  "url": "https://research.draconitic.com/paper/1teaveq22xa39",
  "venue": "ACS Omega",
  "versions": []
}