{
  "abstract": "Neocortical slow oscillations temporally organize neuronal activity across distributed brain regions, but the coordination of basolateral amygdala (BLA) activity with these oscillations remains unclear. We investigated BLA neuronal activity relative to neocortical slow oscillations in male mice, primarily under urethane anesthesia. These oscillations are characterized by rhythmic alternation between active (UP) and inactive (DOWN) states at 0.3–3 Hz. Using unit recordings and calcium imaging, we found that BLA neuronal activity was sparse but preferentially associated with the later phase of the neocortical UP state, while calcium activity showed local spatial organization with greater synchronization among nearby neurons. Medial prefrontal cortical neurons projecting to the BLA were more likely to continue firing into the late phase of the UP state than other prefrontal neurons. Deep whole-cell recordings revealed transient depolarizations in BLA neurons preferentially during the late phase of UP states. Both the probability and timing of these depolarizations varied with UP-state duration, and voltage-clamp recordings revealed temporally anticorrelated changes in excitatory and inhibitory conductances. Thus, these findings define a temporally structured and probabilistic mode of neocortex–BLA coordination during slow oscillations.",
  "abstract_shown": true,
  "affiliations": [
    "Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan",
    "Graduate School of Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan",
    "Institute for AI and Beyond, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan",
    "Center for Information and Neural Networks, National Institute of Information and Communications Technology, Suita City, Osaka 565-0871, Japan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yu Sato",
      "orcid": "0000-0002-5908-9711"
    },
    {
      "affs": [
        0
      ],
      "name": "Tetsuhiko Kashima",
      "orcid": "0000-0002-1802-6482"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Shota Morikawa",
      "orcid": "0000-0002-8917-4298"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Haruki Takeuchi",
      "orcid": "0000-0003-4911-4060"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Yuji Ikegaya",
      "orcid": "0000-0003-2260-8191"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1th6ch4njf3pv.bib",
  "cited_by": 0,
  "doi": "10.1523/jneurosci.0449-26.2026",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13735391/",
  "id": "1th6ch4njf3pv",
  "issns": [
    "0270-6474",
    "1529-2401"
  ],
  "landing_url": "https://doi.org/10.1523/jneurosci.0449-26.2026",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Articles"
    ],
    [
      "heading",
      "Systems/Circuits"
    ],
    [
      "openalex",
      "2805|Neural dynamics and brain function"
    ]
  ],
  "openalex": "W7220656732",
  "pdf_url": "https://www.jneurosci.org/content/jneuro/early/2026/10/05/JNEUROSCI.0449-26.2026.full.pdf",
  "pmcid": "PMC13735391",
  "pmid": "42838740",
  "published": "2026-10-06",
  "publisher": "Society for Neuroscience",
  "ris": "https://research.draconitic.com/paper/1th6ch4njf3pv.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:05Z",
      "native_id": "PMC13735391",
      "source": "pmc",
      "url": "https://doi.org/10.1523/jneurosci.0449-26.2026"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2805|Neural dynamics and brain function",
      "subfield": "neuroscience"
    }
  ],
  "title": "Late UP-state Bias in Cortico-amygdalar Coordination",
  "title_text": "Late UP-state Bias in Cortico-amygdalar Coordination",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:05Z",
  "url": "https://research.draconitic.com/paper/1th6ch4njf3pv",
  "venue": "The Journal of Neuroscience",
  "versions": []
}