{
  "abstract": "Background: Phase III trials have established the efficacy of immune-based therapies for unresectable advanced or recurrent esophageal squamous cell carcinoma (ESCC). However, real-world evidence comparing regimens and clinically applicable prognostic biomarkers remains limited.\n\nMethods: We retrospectively evaluated 245 patients with unresectable advanced/recurrent ESCC treated with first-line 5-fluorouracil plus cisplatin combined with nivolumab or pembrolizumab (CF + ICI; n = 114), first-line ipilimumab plus nivolumab (Ipi + Nivo; n = 46), or nivolumab monotherapy as second-line or later treatment (Nivo; n = 85). Efficacy, safety, and survival outcomes were assessed, focusing on inflammation-based nutritional indices and multivariate prognostic modelling.\n\nResults: The objective response rates were 56%, 53%, and 27%, and the median overall survival was 26, 73, and 13 months in the CF + ICI, Ipi + Nivo, and Nivo groups, respectively. No treatment-related deaths occurred. In multivariate analyses, Glasgow Prognostic Score (GPS) ≥ 2 independently predicted poor survival across all regimens. High platelet-to-lymphocyte ratio (PLR) was independently associated with poor survival only in chemotherapy-free ICI regimens (Ipi + Nivo and Nivo). A pooled model showed a significant interaction between treatment regimen and PLR (p = 0.047).\n\nConclusions: In real-world practice, GPS provides regimen-independent prognostic stratification, whereas PLR shows treatment-dependent prognostic relevance, supporting its potential utility for biomarker-guided and individualized treatment selection in ESCC.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s10388-026-01243-x.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamada-Oka, Suita, Osaka, 565-0871 Japan",
    "Department of Surgery, NHO Osaka National Hospital, Osaka, Japan",
    "Department of Surgery, Osaka General Medical Center, Osaka, Japan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hiroki Matsuda"
    },
    {
      "affs": [
        0
      ],
      "name": "Tomoki Makino",
      "orcid": "0000-0001-7918-4217"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuichiro Hara"
    },
    {
      "affs": [
        0
      ],
      "name": "Shigeto Nakai"
    },
    {
      "affs": [
        0
      ],
      "name": "Takaomi Hagi"
    },
    {
      "affs": [
        0
      ],
      "name": "Kota Momose"
    },
    {
      "affs": [
        0
      ],
      "name": "Kotaro Yamashita"
    },
    {
      "affs": [
        0
      ],
      "name": "Takuro Saito"
    },
    {
      "affs": [
        0
      ],
      "name": "Koji Tanaka"
    },
    {
      "affs": [
        1
      ],
      "name": "Atsushi Takeno"
    },
    {
      "affs": [
        0
      ],
      "name": "Tsuyoshi Takahashi"
    },
    {
      "affs": [
        2
      ],
      "name": "Masaaki Motoori"
    },
    {
      "affs": [
        0
      ],
      "name": "Yukinori Kurokawa"
    },
    {
      "affs": [
        0
      ],
      "name": "Hidetoshi Eguchi"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuichiro Doki"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1tjqf5h2wngq4.bib",
  "cited_by": 0,
  "doi": "10.1007/s10388-026-01243-x",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13723529/",
  "id": "1tjqf5h2wngq4",
  "issns": [
    "1612-9059",
    "1612-9067"
  ],
  "landing_url": "https://doi.org/10.1007/s10388-026-01243-x",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2730|Inflammatory Biomarkers in Disease Prognosis"
    ]
  ],
  "openalex": "W7204498899",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s10388-026-01243-x.pdf",
  "pmcid": "PMC13723529",
  "pmid": "42663915",
  "published": "2026-08-28",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1tjqf5h2wngq4.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:22:09Z",
      "native_id": "PMC13723529",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s10388-026-01243-x"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Inflammatory Biomarkers in Disease Prognosis",
      "subfield": "oncology"
    }
  ],
  "title": "Treatment-dependent and independent prognostic value of inflammation-based nutritional indices in immune checkpoint inhibitor-based therapy for esophageal cancer",
  "title_text": "Treatment-dependent and independent prognostic value of inflammation-based nutritional indices in immune checkpoint inhibitor-based therapy for esophageal cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:20Z",
  "url": "https://research.draconitic.com/paper/1tjqf5h2wngq4",
  "venue": "Esophagus",
  "versions": []
}