{
  "abstract": "Multiple advanced therapies are available for the treatment of Crohn's disease (CD). Treatment patterns in newly diagnosed patients and the factors associated with persistence remain unclear. We present interim results of the iCREST-CD registry describing treatment patterns and persistence with advanced therapies. Patients aged ≥16 years with newly diagnosed CD and who had no prior exposure to advanced therapies were enrolled. Persistence of advanced therapies was estimated using Kaplan-Meier analyses, and associated factors were identified using multivariable Cox proportional hazards models. Persistence was also compared between patients who initiated therapy early or later after diagnosis. Of 672 patients (68.2% male; mean age 29.4 ± 13.1 years), 498 (74.1%) initiated advanced therapy: infliximab (IFX; 121), adalimumab (ADA; 244), ustekinumab (UST; 107), or vedolizumab (VDZ; 26). Advanced therapy was initiated within 1 year of diagnosis in 404 (60.1%). The 36-month treatment persistence rates for IFX, ADA, UST, and VDZ were 77.5%, 75.7%, 79.8%, and 49.0%, respectively. After propensity score adjustment using inverse probability of treatment weighting, the early initiation was associated with greater persistence than delayed initiation, although the difference did not reach statistical significance (hazard ratio, 0.61; 95% confidence interval, 0.35-1.09; P = .067). A high prevalence of early advanced therapy use and a high level of persistence with first-line advanced therapy were identified in this national cohort. Early initiation was associated with greater treatment persistence than delayed initiation, suggesting the potential clinical relevance of earlier advanced therapy use in routine practice. These findings require confirmation in other prospective studies aiming to evaluate early intervention strategies. The study was registered with the University Hospital Medical Information Network Clinical Trials Registry (umin.ac.jp/ctr Identifier: UMIN000032237) prior to initiation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastroenterology, Hyogo Medical University School of Medicine, Nishinomiya, Hyogo, 663-8501, Japan.",
    "Division of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University Sakura Medical Centre, Sakura, Chiba, 285-8741, Japan.",
    "Department of Gastroenterology and Hepatology, Institute of Science Tokyo, Bunkyo-ku, Tokyo, 113-8519, Japan.",
    "Inflammatory Bowel Disease Centre, Yokohama City University Medical Centre, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan.",
    "Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Mitaka, Tokyo, 181-0004, Japan.",
    "Department of Internal Medicine for Inflammatory Bowel Disease, Toyama University Hospital, Sugitani, Toyama, 930-0194, Japan.",
    "Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8574, Japan.",
    "Department of Inflammatory Bowel Disease Centre, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, 818-8502, Japan.",
    "Division of Digestive Endoscopy, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan.",
    "Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University, School of Medicine, Shinjuku-ku, Tokyo, 160-8582, Japan.",
    "Department of Surgery and Inflammatory Bowel Disease Centre, Yokkaichi Hazu Medical Centre, Yokkaichi, Mie, 510-0016, Japan.",
    "IBD Centre, Hokkaido Preventive Welfare Federation of Agricultural Cooperative, Sapporo-Kosei General Hospital, Sapporo, Hokkaido, 060-0033, Japan.",
    "Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, 812-8582, Japan.",
    "Centre for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Minato-ku, Tokyo, 108-8642, Japan.",
    "Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Aichi, 470-1192, Japan.",
    "Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-8471, Japan.",
    "Department of Gastroenterology, Matsuda Paediatric & Gastroenterology IBD Clinic, Ishikawa, 920-0981, Japan.",
    "Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Iwate, 020-0021, Japan.",
    "Division of Gastroenterology and Hepatology, Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, 060-8543, Japan.",
    "IBD Centre, Sapporo Higashi Tokushukai Hospital, Sapporo, Hokkaido, 065-0033, Japan.",
    "Medical Affairs Division, Janssen Pharmaceutical K.K, Chiyoda-ku, Tokyo, 101-0065, Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 28,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shinichiro Shinzaki",
      "orcid": "0000-0002-7051-618X"
    },
    {
      "affs": [
        1
      ],
      "name": "Katsuyoshi Matsuoka",
      "orcid": "0000-0002-2950-7660"
    },
    {
      "affs": [
        2
      ],
      "name": "Toshimitsu Fujii",
      "orcid": "0000-0003-3048-7270"
    },
    {
      "affs": [
        2
      ],
      "name": "Ryuichi Okamoto",
      "orcid": "0000-0002-7047-571X"
    },
    {
      "affs": [
        1
      ],
      "name": "Akihiro Yamada",
      "orcid": "0000-0002-3196-2558"
    },
    {
      "affs": [
        3
      ],
      "name": "Reiko Kunisaki"
    },
    {
      "affs": [
        4
      ],
      "name": "Minoru Matsuura",
      "orcid": "0000-0001-9590-2370"
    },
    {
      "affs": [
        5
      ],
      "name": "Kenji Watanabe"
    },
    {
      "affs": [
        6
      ],
      "name": "Hisashi Shiga",
      "orcid": "0000-0001-6623-2603"
    },
    {
      "affs": [
        7
      ],
      "name": "Noritaka Takatsu",
      "orcid": "0000-0002-1967-5169"
    },
    {
      "affs": [
        8
      ],
      "name": "Shigeki Bamba",
      "orcid": "0000-0002-4108-5894"
    },
    {
      "affs": [
        9
      ],
      "name": "Yohei Mikami",
      "orcid": "0000-0001-5104-4415"
    },
    {
      "affs": [
        10
      ],
      "name": "Takayuki Yamamoto",
      "orcid": "0000-0001-7551-5568"
    },
    {
      "affs": [
        10
      ],
      "name": "Takahiro Shimoyama"
    },
    {
      "affs": [
        11
      ],
      "name": "Satoshi Motoya"
    },
    {
      "affs": [
        12
      ],
      "name": "Takehiro Torisu"
    },
    {
      "affs": [
        13
      ],
      "name": "Taku Kobayashi",
      "orcid": "0000-0002-2073-4234"
    },
    {
      "affs": [
        14
      ],
      "name": "Naoki Ohmiya"
    },
    {
      "affs": [
        15
      ],
      "name": "Masayuki Saruta",
      "orcid": "0000-0001-8172-3240"
    },
    {
      "affs": [
        16
      ],
      "name": "Koichiro Matsuda"
    },
    {
      "affs": [
        17
      ],
      "name": "Takayuki Matsumoto",
      "orcid": "0000-0001-9786-3854"
    },
    {
      "affs": [
        18
      ],
      "name": "Hiroshi Nakase",
      "orcid": "0000-0003-2848-6586"
    },
    {
      "affs": [
        19
      ],
      "name": "Atsuo Maemoto"
    },
    {
      "affs": [
        20
      ],
      "name": "Shinichi Yoshigoe",
      "orcid": "0000-0003-2704-054X"
    },
    {
      "affs": [
        20
      ],
      "name": "Hiroaki Tsuchiya"
    },
    {
      "affs": [
        20
      ],
      "name": "Akiko Hori-Nishi"
    },
    {
      "affs": [
        4
      ],
      "name": "Tadakazu Hisamatsu",
      "orcid": "0000-0002-1178-3536"
    },
    {
      "name": "iCREST-CD Study Group"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1tjweqx47vkhw.bib",
  "cited_by": 0,
  "doi": "10.1093/ecco-jcc/jjag167",
  "fulltext_url": "https://europepmc.org/articles/PMC13744011",
  "id": "1tjweqx47vkhw",
  "issns": [
    "1873-9946",
    "1876-4479"
  ],
  "landing_url": "https://europepmc.org/article/MED/42998010",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2715|Inflammatory Bowel Disease"
    ]
  ],
  "openalex": "W7225455672",
  "pdf_url": "https://europepmc.org/articles/PMC13744011?pdf=render",
  "pmcid": "PMC13744011",
  "pmid": "42998010",
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1tjweqx47vkhw.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:34Z",
      "native_id": "MED:42998010",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42998010"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2715|Inflammatory Bowel Disease",
      "subfield": "general"
    }
  ],
  "title": "Treatment patterns and determinants of persistence with advanced therapies in adults with newly diagnosed Crohn's disease: an interim analysis of an inception cohort registry study (iCREST-CD).",
  "title_text": "Treatment patterns and determinants of persistence with advanced therapies in adults with newly diagnosed Crohn's disease: an interim analysis of an inception cohort registry study (iCREST-CD).",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/1tjweqx47vkhw",
  "venue": "Journal of Crohn's & colitis",
  "versions": []
}