{
  "abstract": "Pulse is an actively maintained open-source adult-physiology simulator, yet its maintainers report no formal sensitivity analysis of its operational inputs. We present the first open reliability atlas across its critical-care envelope: Morris elementary-effects sampling of seven inputs, four severity scenarios, male and female bodies (1,280 simulations). Sensitivity is skewed: three inputs carry a median 93% of each output's total. A four-flag classifier reveals failure modes: two operator-actionable, one sex-stratified. Tidal-volume oscillation (20.6% of runs) is consistent with patient-ventilator dyssynchrony; locking the VC-AC trigger to -2 cmH2O collapses that variability. At FiO2 = 1.0, transient hyperoxia makes 120-second runs underestimate plateau PaO2; 300-second healthy-lung reruns give a median 643 mmHg. Solver divergence was all-male in an input-extreme regime (20/1,280); reducing the male blood-volume baseline to the 4,082 mL floor eliminated it. Runs and flags are released openly, showing users which regions need checking before training on Pulse output.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": "2610.28517",
  "author_total": 6,
  "authors": [
    {
      "name": "Santino Nanini"
    },
    {
      "name": "Arnaud Wiedemann"
    },
    {
      "name": "Yassir Mamouni"
    },
    {
      "name": "Cyril Schweitzer"
    },
    {
      "name": "Philippe Jouvet"
    },
    {
      "name": "Michael Sauthier"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1tss23bj79fhz.bib",
  "cited_by": 0,
  "doi": "10.48550/arxiv.2610.28517",
  "fulltext_url": null,
  "id": "1tss23bj79fhz",
  "issns": [],
  "landing_url": "https://arxiv.org/abs/2610.28517",
  "language": null,
  "licence": "LicenseRef-arXiv-nonexclusive-1.0",
  "licence_label": "arXiv licence",
  "licence_source": "article",
  "licence_url": "http://arxiv.org/licenses/nonexclusive-distrib/1.0/",
  "metadata_licence": "CC0-1.0",
  "native_subjects": [
    [
      "arxiv",
      "q-bio.QM"
    ],
    [
      "openalex",
      "2737|Simulation-Based Education in Healthcare"
    ]
  ],
  "openalex": "W7223094305",
  "pdf_url": "https://arxiv.org/pdf/2610.28517",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-20",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1tss23bj79fhz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:34:08Z",
      "native_id": "2610.28517",
      "source": "arxiv",
      "url": "https://arxiv.org/abs/2610.28517"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "arxiv:q-bio.QM",
      "subfield": "bioinformatics"
    }
  ],
  "title": "An Open Reliability Atlas of Sensitivity and Failure Modes in the Pulse Physiology Engine",
  "title_text": "An Open Reliability Atlas of Sensitivity and Failure Modes in the Pulse Physiology Engine",
  "type": "preprint",
  "updated_at": "2026-10-30T12:34:08Z",
  "url": "https://research.draconitic.com/paper/1tss23bj79fhz",
  "venue": "arXiv",
  "versions": []
}