{
  "abstract": "Renal denervation is a catheter-based therapy that interrupts renal sympathetic traffic and lowers blood pressure through durable neuromodulation. Contemporary catheter-based systems deliver energy to the periadventitial space with an acceptable safety profile. Across blinded placebo-controlled trials in off-medication and on-medication settings, renal denervation achieves greater reductions in ambulatory and office blood pressure than placebo, with a uniform 24-h effect that includes night-time and early-morning periods. Long-term follow-up data from randomized programs and large registries show sustained separation in blood pressure between renal denervation and control groups, preserved renal function, and low re-intervention rates over several years, with select cohorts approaching a decade. This review summarizes the mechanism and target anatomy of renal denervation, key features and results of placebo-controlled trials, and practical considerations for integrating the procedure with contemporary pharmacologic therapy in patients with uncontrolled hypertension.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Takanori Sato"
    },
    {
      "name": "Yuichi Saito"
    },
    {
      "name": "Jiro Aoki"
    },
    {
      "name": "Eiichiro Yamamoto"
    },
    {
      "name": "Yuichiro Maekawa"
    },
    {
      "name": "Kazuomi Kario"
    },
    {
      "name": "Ken Kozuma"
    },
    {
      "name": "Yoshio Kobayashi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1v1n6hrcrqq19.bib",
  "cited_by": 2,
  "doi": "10.1253/circj.cj-25-1042",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/circj/90/10/90_CJ-25-1042/_article",
  "id": "1v1n6hrcrqq19",
  "issns": [
    "1347-4820",
    "1346-9843"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/circj/90/10/90_CJ-25-1042/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/cardiovascular"
    ],
    [
      "openalex",
      "2705|Blood Pressure and Hypertension Studies"
    ]
  ],
  "openalex": "W7117355473",
  "pdf_url": "https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-25-1042/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1v1n6hrcrqq19.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.1253/circj.cj-25-1042",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/circj/90/10/90_CJ-25-1042/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Blood Pressure and Hypertension Studies",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Renal Denervation for Hypertension ― Mechanisms, Evidence, and Clinical Integration ―",
  "title_text": "Renal Denervation for Hypertension ― Mechanisms, Evidence, and Clinical Integration ―",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/1v1n6hrcrqq19",
  "venue": "Circulation Journal",
  "versions": []
}