{
  "abstract": "Background: Anti-melanoma differentiation-associated protein 5 antibody-positive dermatomyositis (anti-MDA5+ DM) spans pulmonary states from no detectable interstitial lung disease (ILD) to rapidly progressive ILD (RP-ILD). We mapped molecular programs and prediction evidence to determine how recurrent biological states may support dynamic stratification.\n\nMethods: PubMed, Web of Science, Ovid and Embase were searched from inception to 22 August 2026. Two reviewers independently screened records and extracted data. Reporting followed PRISMA-ScR; evidence was synthesized across molecular and prediction domains.\n\nResults: Of 4, 166 records, 2, 317 remained after deduplication, 349 underwent full-text assessment, and 95 sources (80 primary studies and 15 syntheses) were included. Type I/III interferon signaling was the most reproducible program. Myeloid inflammatory-remodeling, adaptive activation with lymphocyte or natural-killer-cell loss, vascular-coagulation injury, and immunometabolic disturbance formed additional overlapping axes aligned with pulmonary-state transitions. Clinical and radiomic models showed strong short-term discrimination; harmonized landmarks, calibration, geographic validation, and decision-timed molecular sampling would strengthen clinical use.\n\nConclusion: The evidence supports an integrated map linking recurrent molecular programs to dynamic pulmonary risk. A calibrated clinical–imaging backbone, augmented by parsimonious molecular modules with incremental value and updated at prespecified landmarks, offers a practical framework for prospective endotype validation and treatment-aware prediction in anti-MDA5+ DM-ILD.\n\nSystematic review registration: https://doi.org/10.37766/inplasy2026.10.0018 , identifier INPLASY2026100018.",
  "abstract_shown": true,
  "affiliations": [
    "First Teaching Hospital of Tianjin University of Traditional Chinese Medicine",
    "National Clinical Research Center for Chinese Medicine"
  ],
  "article_type": "systematic review",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Zhiwei Zuo"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jianguo Yang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jianbin Li"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Renhe Li"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Wei Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1v25djxeyag72.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1979138",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690796/?tool=EBI",
  "id": "1v25djxeyag72",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1979138/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Inflammatory Myopathies and Dermatomyositis"
    ]
  ],
  "openalex": "W7221065629",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690796/pdf/?tool=EBI",
  "pmcid": "PMC13690796",
  "pmid": null,
  "published": "2026-10-09",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/1v25djxeyag72.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:15Z",
      "native_id": "10.3389/fimmu.2026.1979138",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1979138/full"
    },
    {
      "first_seen": "2026-10-30T12:19:59Z",
      "native_id": "PMC:PMC13690796",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13690796"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Inflammatory Myopathies and Dermatomyositis",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Candidate molecular endotypes and dynamic risk prediction in anti-MDA5-positive dermatomyositis-associated interstitial lung disease: a systematic scoping review",
  "title_text": "Candidate molecular endotypes and dynamic risk prediction in anti-MDA5-positive dermatomyositis-associated interstitial lung disease: a systematic scoping review",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:59Z",
  "url": "https://research.draconitic.com/paper/1v25djxeyag72",
  "venue": "Frontiers in Immunology",
  "versions": []
}