{
  "abstract": "Diabetic foot ulcers (DFU) are debilitating chronic wounds which affect up to a third of diabetic patients. Due to the underlying diabetic pathophysiology, normal wound healing is perturbed. In particular, there is insufficient re‐vascularisation of the wound bed, ultimately leading to the development of chronic wounds. Current treatment protocols are insufficient to stimulate re‐vascularisation and wound closure, ultimately leading to ~20% of patients with a DFU requiring lower limb amputation. Extracellular matrix (ECM)‐derived biomaterials have demonstrated great promise to promote tissue vascularisation and wound repair. In the present study, the overarching goal was to develop a decellularised ECM from human induced pluripotent stem cell (hiPSC)‐derived vascular cells, and incorporate it into a hyaluronic acid‐based hydrogel for wound healing. Vascular differentiation of hiPSCs yielded a heterogenous population containing both CD31 expressing endothelial cells (iEC), and CD31‐negative stromal cells (iSC). ECM deposition by iSCs was stimulated by treatment with ascorbic acid and macromolecular crowder carrageenan. Post‐decellularisation, the ECM composition was analysed by immunofluorescent and histological staining, indicating the presence of ECM components such as fibronectin, fibrillar collagens, perlecan and glycosaminoglycans, all having implications in angiogenic processes. Decellularised ECM accelerated the capacity of iECs to form tube‐like structures when added to cell culture media in 2D. Decoration of hyaluronic acid (HyA)‐based hydrogels with this decellularised ECM enhanced metabolic activity and attachment of both HUVECs and human dermal fibroblasts seeded on these hydrogels. Taken together, this ECM‐decorated HyA‐based hydrogel has the potential to enhance angiogenesis and revascularisation in chronic wound applications such as DFU.",
  "abstract_shown": true,
  "affiliations": [
    "Tissue Engineering Research Group, Department of Anatomy and Regenerative Medicine Royal College of Surgeons in Ireland Dublin Ireland",
    "CÙRAM, Centre for Research in Medical Devices University of Galway Galway Ireland",
    "Department of Medicine, Education and Research Centre Royal College of Surgeons in Ireland Dublin Ireland",
    "Trinity Centre for Biomedical Engineering Trinity College Dublin Dublin Ireland"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Louise Hosty",
      "orcid": "0009-0007-5074-7478"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yu‐Yin Joanne Chang",
      "orcid": "0009-0002-8607-4950"
    },
    {
      "affs": [
        0
      ],
      "name": "Martina Konečná"
    },
    {
      "affs": [
        0
      ],
      "name": "Matthew McGrath",
      "orcid": "0000-0002-0607-5877"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Cormac Murphy"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Anja Schweikert",
      "orcid": "0000-0002-3187-1111"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Mari Ozaki",
      "orcid": "0000-0003-0649-7882"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Killian Hurley",
      "orcid": "0000-0003-4755-5559"
    },
    {
      "affs": [
        0
      ],
      "name": "Fabio Quondamatteo"
    },
    {
      "affs": [
        0,
        1,
        3
      ],
      "name": "Shane Browne",
      "orcid": "0000-0002-1005-1712"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1vmg183z9wz2e.bib",
  "cited_by": 0,
  "doi": "10.1111/joa.70273",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13736179/",
  "id": "1vmg183z9wz2e",
  "issns": [
    "0021-8782",
    "1469-7580"
  ],
  "landing_url": "https://doi.org/10.1111/joa.70273",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2746|Tissue Engineering and Regenerative Medicine"
    ]
  ],
  "openalex": "W7225318117",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/joa.70273",
  "pmcid": "PMC13736179",
  "pmid": "42983968",
  "published": "2026-11-04",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/1vmg183z9wz2e.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:41Z",
      "native_id": "PMC13736179",
      "source": "pmc",
      "url": "https://doi.org/10.1111/joa.70273"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Tissue Engineering and Regenerative Medicine",
      "subfield": "surgery"
    }
  ],
  "title": "Development of a pro‐angiogenic stem cell‐derived vascular cell extracellular matrix‐decorated hyaluronic acid hydrogel",
  "title_text": "Development of a pro‐angiogenic stem cell‐derived vascular cell extracellular matrix‐decorated hyaluronic acid hydrogel",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:41Z",
  "url": "https://research.draconitic.com/paper/1vmg183z9wz2e",
  "venue": "Journal of Anatomy",
  "versions": []
}