{
  "abstract": "Undifferentiated pleomorphic sarcoma (UPS) and myxofibrosarcoma (MFS) frequently exhibit infiltrative growth, but whether pathological and magnetic resonance imaging (MRI)-based findings represent the same tumor characteristics remain unclear. We examined the relationships among report-documented pathological infiltration (PI), MRI-defined diffuse infiltration (DI), and radiological infiltration (RI) based on the tail sign, and explored their associations with oncologic outcomes. This single-center retrospective cohort study included 68 treatment-naïve patients with primary UPS or MFS without distant or lymph-node metastasis at presentation who underwent curative-intent resection. The primary outcome was progression-free survival (PFS), with overall survival (OS), distant metastasis-free survival (DMFS), and local recurrence-free survival (LRFS) evaluated as secondary outcomes. Time-to-event associations were evaluated using Firth's penalized Cox regression with parsimonious covariate adjustment and sensitivity analyses restricted to patients with R0 resection. DI, RI, and PI were observed in 75.0%, 76.5%, and 60.3% of patients, respectively. RI positivity was more frequent among patients with PI, whereas DI showed no clear relationship with PI or RI. In an exploratory multivariable model, DI (hazard ratio [HR], 3.30; 95% confidence interval [CI], 1.05-16.51; p = 0.040) and RI (HR, 4.26; 95% CI, 1.31-22.29; p = 0.013) were associated with worse PFS. Local recurrences occurred only in patients with PI, although adjusted estimates were imprecise. These findings suggest that pathological and MRI-based infiltrative markers may capture different and potentially complementary aspects of tumor behavior. External validation using standardized imaging and pathological review is required.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Orthopaedic Surgery, Institute of Science Tokyo, Tokyo 113-8510, Japan.",
    "Department of Orthopaedic Surgery, Cancer Institute Hospital of JFCR, Tokyo 135-8550, Japan.",
    "Department of Pathology, Cancer Institute Hospital of JFCR, Tokyo 135-8550, Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Akane Ariga",
      "orcid": "0000-0002-2546-3090"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yuki Funauchi",
      "orcid": "0000-0001-7031-672X"
    },
    {
      "affs": [
        2
      ],
      "name": "Kyoko Yamashita",
      "orcid": "0000-0001-6535-5951"
    },
    {
      "affs": [
        1
      ],
      "name": "Masanori Saito",
      "orcid": "0000-0002-4139-4013"
    },
    {
      "affs": [
        1
      ],
      "name": "Keiko Hayakawa"
    },
    {
      "affs": [
        1
      ],
      "name": "Taisuke Tanizawa"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Norio Kurosawa",
      "orcid": "0009-0005-9209-4474"
    },
    {
      "affs": [
        0
      ],
      "name": "Toshitaka Yoshii"
    },
    {
      "affs": [
        1
      ],
      "name": "Keisuke Ae"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1w7z7n9d8j2hg.bib",
  "cited_by": 0,
  "doi": "10.3390/curroncol33100572",
  "fulltext_url": "https://europepmc.org/articles/PMC13703746",
  "id": "1w7z7n9d8j2hg",
  "issns": [
    "1198-0052",
    "1718-7729"
  ],
  "landing_url": "https://europepmc.org/article/MED/42930139",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Sarcoma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7215067036",
  "pdf_url": "https://europepmc.org/articles/PMC13703746?pdf=render",
  "pmcid": "PMC13703746",
  "pmid": "42930139",
  "published": "2026-09-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1w7z7n9d8j2hg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42930139",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42930139"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Sarcoma Diagnosis and Treatment",
      "subfield": "general"
    }
  ],
  "title": "Pathological and MRI-Based Infiltrative Markers Show Distinct Associations with Oncologic Outcomes in Undifferentiated Pleomorphic Sarcoma and Myxofibrosarcoma.",
  "title_text": "Pathological and MRI-Based Infiltrative Markers Show Distinct Associations with Oncologic Outcomes in Undifferentiated Pleomorphic Sarcoma and Myxofibrosarcoma.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/1w7z7n9d8j2hg",
  "venue": "Current oncology (Toronto, Ont.)",
  "versions": []
}