{
  "abstract": "Circadian (~24 h) rhythms are a fundamental feature of life, and their disruption increases the risk of infectious diseases, metabolic disorders, and cancer. We previously identified circadian oscillations in intracellular potassium concentrations in cells across kingdoms. Using highly divergent eukaryotic cell types, we now show that potassium levels act to regulate the period and phase of clock gene expression rhythms, therefore establishing intracellular potassium as a bona fide regulator of cellular circadian rhythms. Intracellular potassium also regulates critical events in the cell cycle. Strikingly, we observe that manipulating potassium levels inhibits cell proliferation in a circadian phase-dependent manner. As the timing of cell division is tuned by the circadian clock, we hypothesised that potassium rhythms could mechanistically link cell proliferation rhythms to the circadian cycle. In line with this hypothesis, we find that potassium levels are not only sufficient to instruct the timing of cell proliferation, but also essential to maintain coherent coupling between circadian rhythms and proliferation rhythms. These results establish circadian potassium rhythms as a primary factor coupling the cell- and circadian cycles in eukaryotic cells.",
  "abstract_shown": true,
  "affiliations": [
    "School of Biological Sciences, University of Edinburgh, Max Born Crescent, Edinburgh, UK",
    "Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA, USA",
    "UKRI MRC Laboratory of Molecular Biology, Francis Crick Ave, Cambridge, UK",
    "University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne Excellence Cluster for Aging and Aging-Associated Diseases (CECAD), Institute for Mitochondrial Diseases and Ageing, Joseph-Stelzmann-Str, Cologne, Germany",
    "Center for Circadian Biology, University of California San Diego, La Jolla, CA, USA",
    "Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, CA, USA",
    "Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA, USA. Priya.Crosby@ed.ac.uk",
    "School of Biological Sciences, University of Edinburgh, Max Born Crescent, Edinburgh, UK. Priya.Crosby@ed.ac.uk",
    "School of Biological Sciences, University of Edinburgh, Max Born Crescent, Edinburgh, UK. Gerben.vanOoijen@ed.ac.uk"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sergio Gil Rodríguez"
    },
    {
      "affs": [
        0
      ],
      "name": "Louise L. Hansen",
      "orcid": "0000-0001-8043-2660"
    },
    {
      "affs": [
        0
      ],
      "name": "Olivia J. P. Fraser"
    },
    {
      "affs": [
        0
      ],
      "name": "Yen Peng Chew",
      "orcid": "0000-0003-3799-5876"
    },
    {
      "affs": [
        1
      ],
      "name": "Rebecca K. Spangler",
      "orcid": "0000-0001-5021-0661"
    },
    {
      "affs": [
        0
      ],
      "name": "Ellen Grünewald"
    },
    {
      "affs": [
        2
      ],
      "name": "Andrew D. Beale",
      "orcid": "0000-0002-2051-0919"
    },
    {
      "affs": [
        1
      ],
      "name": "Beverley M. Rabbitts",
      "orcid": "0000-0002-0896-6024"
    },
    {
      "affs": [
        3
      ],
      "name": "Alessandra Stangherlin",
      "orcid": "0000-0001-7296-1183"
    },
    {
      "affs": [
        2
      ],
      "name": "John Stuart O'Neill",
      "orcid": "0000-0003-2204-6096"
    },
    {
      "affs": [
        4,
        1,
        5
      ],
      "name": "Carrie L. Partch",
      "orcid": "0000-0002-4677-2861"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Priya Crosby",
      "orcid": "0000-0002-7532-7708"
    },
    {
      "affs": [
        8
      ],
      "name": "Gerben Van Ooijen A",
      "orcid": "0000-0001-7967-0637"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1wey7rzta90r4.bib",
  "cited_by": 5,
  "doi": "10.1038/s41467-026-73351-2",
  "fulltext_url": null,
  "id": "1wey7rzta90r4",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://doi.org/10.1038/s41467-026-73351-2",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2807|Circadian rhythm and melatonin"
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  "pdf_url": "https://www.nature.com/articles/s41467-026-73351-2_reference.pdf",
  "pmcid": "PMC11014554",
  "pmid": "38617352",
  "published": "2026-05-22",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/1wey7rzta90r4.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T13:21:11Z",
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      "url": "https://doi.org/10.1038/s41467-026-73351-2"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2807|Circadian rhythm and melatonin",
      "subfield": "physiology"
    }
  ],
  "title": "Intracellular potassium levels orchestrate circadian rhythmicity and cell division",
  "title_text": "Intracellular potassium levels orchestrate circadian rhythmicity and cell division",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:14Z",
  "url": "https://research.draconitic.com/paper/1wey7rzta90r4",
  "venue": "Nature Communications",
  "versions": []
}