{
  "abstract": "Introduction\n\nEarly neurofibrillary tau degeneration in the entorhinal cortex (EC) is a hallmark of Alzheimer's disease (AD) and aging. We propose a biomechanical cascade hypothesis, suggesting proximity to the tentorial incisura (TI) may render the EC susceptible to chronic mechanical stress, potentially contributing to tau pathology.Methods\n\nWe developed a neuroanatomical contact coefficient (NCC) to quantify EC-TI proximity using Alzheimer's Disease Neuroimaging Initiative multimodal imaging data (n = 47), stratifying participants into high and low adjacency groups.Results\n\nControlling for risk factors, EC tau positron emission tomography signal predicted conversion from mild cognitive impairment to AD only in the high-adjacency group (P = 0.036).Discussion\n\nFindings identify EC-TI proximity as a potential, novel, anatomically grounded biomarker of AD risk. These findings are consistent with a previously unrecognized biomechanical contribution to EC tau vulnerability in sporadic AD and aging, opening new avenues for early detection, risk stratification, and mechanistically targeted prevention strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biomedical Engineering, Columbia University, New York, New York, USA.",
    "Neuroradiology Division, Department of Radiology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Lenox Hill Hospital, New York, New York, USA.",
    "Department of Pathology, Nash Family Department of Neuroscience, Department of Artificial Intelligence & Human Health, Neuropathology Brain Bank & Research CoRE, Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.",
    "Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Luyue Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Ana M Franceschi"
    },
    {
      "affs": [
        2
      ],
      "name": "John F Crary"
    },
    {
      "affs": [
        3
      ],
      "name": "Frank A Provenzano"
    },
    {
      "name": "Alzheimer's Disease Neuroimaging Initiative"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1wmpd6bggr2s3.bib",
  "cited_by": 1,
  "doi": "10.1002/alz.71827",
  "fulltext_url": "https://europepmc.org/articles/PMC13636655",
  "id": "1wmpd6bggr2s3",
  "issns": [
    "1552-5260",
    "1552-5279"
  ],
  "landing_url": "https://europepmc.org/article/MED/42831470",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Alzheimer's disease research and treatments"
    ]
  ],
  "openalex": "W4414029382",
  "pdf_url": "https://europepmc.org/articles/PMC13636655?pdf=render",
  "pmcid": "PMC13636655",
  "pmid": "42831470",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1wmpd6bggr2s3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:10Z",
      "native_id": "MED:42831470",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42831470"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Alzheimer's disease research and treatments",
      "subfield": "physiology"
    }
  ],
  "title": "Structural compression and entorhinal vulnerability: Linking tentorial adjacency to tau burden and dementia progression.",
  "title_text": "Structural compression and entorhinal vulnerability: Linking tentorial adjacency to tau burden and dementia progression.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:10Z",
  "url": "https://research.draconitic.com/paper/1wmpd6bggr2s3",
  "venue": "Alzheimer's & dementia : the journal of the Alzheimer's Association",
  "versions": []
}