{
  "abstract": "Animal bile has been used for millennia in traditional Chinese medicine as a cough suppressant and bronchodilator. As the primary functional constituents of bile, bile acids (BAs) are believed to mediate these physiological effects. Although the role of BAs in enterohepatic circulation is well-characterized, and recent advances have highlighted their immunomodulatory functions, their pathophysiological significance in the respiratory system has been largely overlooked. This review synthesizes emerging evidence on the multidimensional roles of BAs and their receptor-mediated signaling pathways, with a focus on their contribution to the pathogenesis of major respiratory diseases such as asthma, pulmonary fibrosis, and lung injury.",
  "abstract_shown": true,
  "affiliations": [
    "School of Pharmacy, Shihezi University, Shihezi 832002, China",
    "Department of Pharmacy, First Affiliated Hospital, Shihezi University, Shihezi 832008, China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Juanjuan Wan"
    },
    {
      "affs": [
        0
      ],
      "name": "Hui Zong"
    },
    {
      "affs": [
        0
      ],
      "name": "Dongdong He"
    },
    {
      "affs": [
        0
      ],
      "name": "Dingtao Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Jing Yu"
    },
    {
      "affs": [
        0
      ],
      "name": "Guodong Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Liting Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Chuansheng Huang",
      "orcid": "0009-0006-2027-0958"
    },
    {
      "affs": [
        1
      ],
      "name": "Xinchun Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Liping Wang",
      "orcid": "0009-0009-9526-7579"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1wwszah24exea.bib",
  "cited_by": 0,
  "doi": "10.3390/biom16101497",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702143/?tool=EBI",
  "id": "1wwszah24exea",
  "issns": [
    "2218-273X"
  ],
  "landing_url": "https://www.mdpi.com/2218-273X/16/10/1497",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Drug Transport and Resistance Mechanisms"
    ]
  ],
  "openalex": "W7221793363",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702143/pdf/?tool=EBI",
  "pmcid": "PMC13702143",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/1wwszah24exea.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:59Z",
      "native_id": "10.3390/biom16101497",
      "source": "crossref",
      "url": "https://www.mdpi.com/2218-273X/16/10/1497"
    },
    {
      "first_seen": "2026-10-30T12:21:40Z",
      "native_id": "PMC:PMC13702143",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13702143"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Drug Transport and Resistance Mechanisms",
      "subfield": "oncology"
    }
  ],
  "title": "Bile Acids and Their Receptors in Respiratory Diseases: Mechanistic and Therapeutic Perspectives",
  "title_text": "Bile Acids and Their Receptors in Respiratory Diseases: Mechanistic and Therapeutic Perspectives",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:40Z",
  "url": "https://research.draconitic.com/paper/1wwszah24exea",
  "venue": "Biomolecules",
  "versions": []
}