{
  "abstract": "Triple-negative breast cancer (TNBC) is an aggressive malignancy with limited therapeutic options. Here, we identified a marked exhaustion phenotype in peripheral Vγ9Vδ2 (Vδ2) T cells from patients with TNBC, characterized by elevated PD-1 and TIM-3 expression. Untargeted serum metabolomics revealed significantly reduced taurine levels, which were inversely associated with Vδ2 T-cell exhaustion. Bioinformatic analyses further showed that higher expression of the taurine transporter SLC6A6 correlated with enhanced immune infiltration and favorable prognosis in TNBC. Mechanistically, taurine uptake via SLC6A6 alleviated immune exhaustion in Vδ2 T cells and enhanced PLCγ1 phosphorylation, thereby promoting IFN-γ and TNF-α production. In vitro, taurine-treated Vδ2 T cells exhibited enhanced cytotoxicity against TNBC cells. In vivo, taurine supplementation suppressed tumor growth in a γδ T cell-dependent manner. Collectively, these findings identify the taurine-SLC6A6 axis as a key regulator of Vδ2 T-cell function in TNBC and suggest taurine supplementation as a potential strategy to enhance γδ T cell-mediated antitumor immunity.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Oncology, Research Center of Cancer Diagnosis and Therapy, The First Affiliated Hospital, Jinan University, Guangzhou, China.",
    "Department of Breast Cancer, The First People's Hospital of Foshan, Foshan, China.",
    "Department of Geriatrics, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.",
    "Institute of Cell and Gene Technology, Shenzhen University of Advanced Technology, Shenzhen, China.",
    "The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.",
    "Department of Oncology, Research Center of Cancer Diagnosis and Therapy, The First Affiliated Hospital, Jinan University, Guangzhou, China. quanqiang@jnu.edu.cn.",
    "Department of Oncology, Research Center of Cancer Diagnosis and Therapy, The First Affiliated Hospital, Jinan University, Guangzhou, China. zhaojianfu@jnu.edu.cn.",
    "Institute of Cell and Gene Technology, Shenzhen University of Advanced Technology, Shenzhen, China. lipeng@suat-sz.edu.cn.",
    "The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China. lipeng@suat-sz.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Haibo Duan"
    },
    {
      "affs": [
        2
      ],
      "name": "Ke Li"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Wenhui Yuan"
    },
    {
      "affs": [
        0
      ],
      "name": "Lanhong Pan"
    },
    {
      "affs": [
        0
      ],
      "name": "Min Su"
    },
    {
      "affs": [
        5
      ],
      "name": "Qiang Quan"
    },
    {
      "affs": [
        6
      ],
      "name": "Jianfu Zhao"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Peng Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1x4avnq7yv438.bib",
  "cited_by": 0,
  "doi": "10.1186/s12964-026-03125-2",
  "fulltext_url": "https://europepmc.org/articles/PMC13718070",
  "id": "1x4avnq7yv438",
  "issns": [
    "1478-811X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42958404",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2730|Cancer Immunotherapy and Biomarkers"
    ]
  ],
  "openalex": "W7172160032",
  "pdf_url": "https://europepmc.org/articles/PMC13718070?pdf=render",
  "pmcid": "PMC13718070",
  "pmid": "42958404",
  "published": "2026-08-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/1x4avnq7yv438.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:47Z",
      "native_id": "MED:42958404",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42958404"
    },
    {
      "first_seen": "2026-11-02T12:22:13Z",
      "native_id": "PMC13718070",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12964-026-03125-2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cancer Immunotherapy and Biomarkers",
      "subfield": "oncology"
    }
  ],
  "title": "Taurine preserves γδ T cell fitness in triple-negative breast cancer.",
  "title_text": "Taurine preserves γδ T cell fitness in triple-negative breast cancer.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:13Z",
  "url": "https://research.draconitic.com/paper/1x4avnq7yv438",
  "venue": "Cell communication and signaling : CCS",
  "versions": []
}