{
  "abstract": "Background\n\nAging involves progressive functional decline driven by oxidative stress and mitochondrial dysfunction, and dietary flavonoids are promising aging interventions due to their multi-target regulatory pathways.Methods\n\nThis study systematically evaluated the anti-aging activity of myricitrin (MYR) and its underlying mechanisms using Caenorhabditis elegans, testing MYR at 0.25 mg/mL, employing a rotenone-induced model of mitochondrial oxidative stress, and performing reporter strain analyses, qRT-PCR, and molecular docking analysis with acetylcholinesterases (ACE-1/2).Results\n\nMYR at 0.25 mg/mL significantly extended lifespan and improved locomotor performance without detectable toxicity regarding growth, feeding, or reproduction; reduced reactive oxygen species accumulation and restored antioxidant enzyme activities in the rotenone-induced model; was accompanied by the nuclear translocation of DAF-16 and the upregulation of associated downstream antioxidant genes (sod-3, gst-4); enhanced mitochondrial quality control by upregulating sir-2.1 and modulating genes associated with the mitochondrial unfolded protein response (atfs-1, hsp-6) and mitochondrial dynamics (fzo-1, drp-1); and indicated a favorable interaction between MYR and acetylcholinesterases (ACE-1/2).Conclusions\n\nMYR represents a promising candidate compound for mitigating aging-related phenotypes, with its beneficial effects linked to a DAF-16-associated antioxidant response and SIR-2.1-correlated mitochondrial quality control network.",
  "abstract_shown": true,
  "affiliations": [
    "School of Life Sciences, Sichuan Normal University, Chengdu 610101, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lijun Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiuyi Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Yihan Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Huaying Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yu Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiayuan Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yanan Wang",
      "orcid": "0000-0001-7132-3008"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1x5m46fsd0zxq.bib",
  "cited_by": 0,
  "doi": "10.3390/antiox15101230",
  "fulltext_url": "https://europepmc.org/articles/PMC13700646",
  "id": "1x5m46fsd0zxq",
  "issns": [
    "2076-3921"
  ],
  "landing_url": "https://europepmc.org/article/MED/42939805",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1302|Genetics, Aging, and Longevity in Model Organisms"
    ]
  ],
  "openalex": "W7214073655",
  "pdf_url": "https://europepmc.org/articles/PMC13700646?pdf=render",
  "pmcid": "PMC13700646",
  "pmid": "42939805",
  "published": "2026-09-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1x5m46fsd0zxq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42939805",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42939805"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1302|Genetics, Aging, and Longevity in Model Organisms",
      "subfield": "cell-biology"
    }
  ],
  "title": "Myricitrin Delays Caenorhabditis elegans Aging: Association with DAF-16, SIR-2.1, and Potential Cholinergic Modulation.",
  "title_text": "Myricitrin Delays Caenorhabditis elegans Aging: Association with DAF-16, SIR-2.1, and Potential Cholinergic Modulation.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:24Z",
  "url": "https://research.draconitic.com/paper/1x5m46fsd0zxq",
  "venue": "Antioxidants (Basel, Switzerland)",
  "versions": []
}