{
  "abstract": "Aging is associated with chronic low-grade inflammation and cellular senescence, and macrophages are thought to contribute to these changes in the kidney. This study examined whether pharmacological inhibition of colony-stimulating factor 1 receptor (CSF1R) with PLX5622 modulates age-associated inflammatory and senescence-related changes in murine kidneys. Young and aged wild-type mice were treated with low-dose or high-dose PLX5622, and kidneys were analyzed for macrophage abundance, inflammatory markers, senescence-associated markers, and kidney injury markers. Aged kidneys showed increased expression of p16, IL-6, CX3CR1, and LCN2, together with higher numbers of F4/80-positive macrophages. Additional immunohistochemical analyses demonstrated increased CSF1R and p16 expression in F4/80-positive cells and increased senescence-associated β-galactosidase activity in aged kidneys. High-dose PLX5622 significantly reduced macrophage numbers in young and aged kidneys and lowered CX3CR1 expression, but was associated with increased blood urea nitrogen levels. In contrast, low-dose PLX5622 partially reduced macrophage abundance and significantly decreased IL-6, TNF-α, CX3CR1, p16, and senescence-associated β-galactosidase activity in aged kidneys without increasing blood urea nitrogen, while TIM1 remained unchanged. These findings indicate that CSF1R-sensitive macrophage populations contribute to age-associated inflammatory and senescence-related changes in the kidney and suggest that partial macrophage depletion may attenuate these processes without overt evidence of renal toxicity.",
  "abstract_shown": true,
  "affiliations": [
    "Corresponding author.",
    "Department of Neurology, Jena University Hospital, Friedrich-Schiller University Jena, Am Klinikum 1, Jena, 07747, Germany"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Milan R. Stojiljkovic"
    },
    {
      "affs": [
        1
      ],
      "name": "Christian Schmeer"
    },
    {
      "affs": [
        0
      ],
      "name": "Otto W. Witte"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1x745w8gwnvab.bib",
  "cited_by": 0,
  "doi": "10.1016/j.imbio.2026.153259",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S0171298526001051",
  "id": "1x745w8gwnvab",
  "issns": [
    "0171-2985",
    "1878-3279"
  ],
  "landing_url": "https://doi.org/10.1016/j.imbio.2026.153259",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2403|Phagocytosis and Immune Regulation"
    ]
  ],
  "openalex": "W7221830722",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/1x745w8gwnvab.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:42Z",
      "native_id": "804832389d6c45ac8af4729b2199f704",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.imbio.2026.153259"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Phagocytosis and Immune Regulation",
      "subfield": "immunology"
    }
  ],
  "title": "Pharmacological depletion of macrophages leads to a reduction in inflammation and senescence in aged murine kidneys",
  "title_text": "Pharmacological depletion of macrophages leads to a reduction in inflammation and senescence in aged murine kidneys",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:42Z",
  "url": "https://research.draconitic.com/paper/1x745w8gwnvab",
  "venue": "Immunobiology",
  "versions": []
}