{
  "abstract": "Organoid technology has emerged as a research hotspot in the biomedical field in recent years, providing important methodologies for disease modeling, drug screening, and regenerative medicine. Alveolar organoids serve as crucial models for studying respiratory diseases, and their technological evolution and application expansion reflect key advances in this field. This article systematically reviews the developmental history of organoids, provides an in-depth comparison of the applicability and limitations of different culture and characterization strategies for alveolar organoids, summarizes and critically analyzes alveolar organoid models established for common respiratory diseases, and offers perspectives on future directions in this area.",
  "abstract_shown": true,
  "affiliations": [
    "Beijing Tuberculosis and Thoracic Tumor Research Institute, Courtyard 1, No.9 Beiguan Street, Tongzhou District, Beijing, 101199, China.",
    "Department of Respiratory and Critical Care Medicine, Beijing Chest Hospital, Capital Medical University, Courtyard 1, No.9 Beiguan Street, Tongzhou District, Beijing, 101199, China.",
    "Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Peking University, Beijing, 100191, China.",
    "Beijing Tuberculosis and Thoracic Tumor Research Institute, Courtyard 1, No.9 Beiguan Street, Tongzhou District, Beijing, 101199, China. wangdongchang@bjxkyy.cn.",
    "Department of Respiratory and Critical Care Medicine, Beijing Chest Hospital, Capital Medical University, Courtyard 1, No.9 Beiguan Street, Tongzhou District, Beijing, 101199, China. wangdongchang@bjxkyy.cn.",
    "Beijing Tuberculosis and Thoracic Tumor Research Institute, Courtyard 1, No.9 Beiguan Street, Tongzhou District, Beijing, 101199, China. yedahuan@yeah.net.",
    "Department of Respiratory and Critical Care Medicine, Beijing Chest Hospital, Capital Medical University, Courtyard 1, No.9 Beiguan Street, Tongzhou District, Beijing, 101199, China. yedahuan@yeah.net."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yuanfang Xing"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Luyu Yang"
    },
    {
      "affs": [
        2
      ],
      "name": "Zhimin Cao"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Dongchang Wang"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Huan Ye"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1x7fhv86ne4x8.bib",
  "cited_by": 0,
  "doi": "10.1186/s12967-026-08616-x",
  "fulltext_url": "https://europepmc.org/articles/PMC13681799",
  "id": "1x7fhv86ne4x8",
  "issns": [
    "1479-5876"
  ],
  "landing_url": "https://europepmc.org/article/MED/42897657",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2740|Neonatal Respiratory Health Research"
    ]
  ],
  "openalex": "W7170078143",
  "pdf_url": "https://europepmc.org/articles/PMC13681799?pdf=render",
  "pmcid": "PMC13681799",
  "pmid": "42897657",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/1x7fhv86ne4x8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:42Z",
      "native_id": "MED:42897657",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897657"
    },
    {
      "first_seen": "2026-10-30T13:46:24Z",
      "native_id": "96f3d1f25a1749f6946624069d6517ef",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s12967-026-08616-x"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Neonatal Respiratory Health Research",
      "subfield": "general"
    }
  ],
  "title": "Alveolar organoids: from model systems to applications in respiratory diseases.",
  "title_text": "Alveolar organoids: from model systems to applications in respiratory diseases.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:24Z",
  "url": "https://research.draconitic.com/paper/1x7fhv86ne4x8",
  "venue": "Journal of translational medicine",
  "versions": []
}