{
  "abstract": "R2TP is a chaperone complex consisting of the AAA+ ATPases RUVBL1 and RUVBL2, as well as RPAP3 and PIH1D1 proteins. R2TP is responsible for the assembly of macromolecular complexes mainly acting through different adaptors. Using proximity-labeling mass spectrometry, we identified deleted in primary ciliary dyskinesia (DPCD) as an adaptor of R2TP. Here, we demonstrate that R2TP-DPCD influences ciliogenesis initiation through a unique mechanism by interaction with Akt kinase to regulate its phosphorylation levels rather than its stability. We further show that DPCD is a heart-shaped monomeric protein with two domains. A highly conserved region in the cysteine- and histidine-rich domains-containing proteins and SGT1 (CS) domain of DPCD interacts with the RUVBL2 DII domain with high affinity to form a stable R2TP-DPCD complex both in cellulo and in vitro. Considering that DPCD is one among several CS-domain-containing proteins found to associate with RUVBL1/2, we propose that RUVBL1/2 are CS-domain-binding proteins that regulate complex assembly and downstream signaling.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Yu-Qian Mao"
    },
    {
      "name": "Thiago Seraphim"
    },
    {
      "name": "Yimei Wan"
    },
    {
      "name": "Ruikai Wu"
    },
    {
      "name": "Etienne Coyaud"
    },
    {
      "name": "Muhammad Bin Munim"
    },
    {
      "name": "Antonio Mollica"
    },
    {
      "name": "Estelle Laurent"
    },
    {
      "name": "Mohan Babu"
    },
    {
      "name": "Vito Mennella"
    },
    {
      "name": "Brian Raught"
    },
    {
      "name": "Walid Houry"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1x7sg4t8w0a0s.bib",
  "cited_by": 12,
  "doi": "10.1016/j.celrep.2024.113713",
  "fulltext_url": null,
  "id": "1x7sg4t8w0a0s",
  "issns": [
    "2211-1247",
    "2211-1247"
  ],
  "landing_url": "https://hal.science/hal-05790874v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1311|Genetic and Kidney Cyst Diseases"
    ]
  ],
  "openalex": "W4391430199",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-10",
  "publisher": "Elsevier Inc",
  "ris": "https://research.draconitic.com/paper/1x7sg4t8w0a0s.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:53Z",
      "native_id": "hal-05790874",
      "source": "hal",
      "url": "https://hal.science/hal-05790874v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Genetic and Kidney Cyst Diseases",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "DPCD is a regulator of R2TP in ciliogenesis initiation through Akt signaling",
  "title_text": "DPCD is a regulator of R2TP in ciliogenesis initiation through Akt signaling",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:53Z",
  "url": "https://research.draconitic.com/paper/1x7sg4t8w0a0s",
  "venue": "Cell Reports",
  "versions": []
}