{
  "abstract": "oogenesis, we report that basal pulsatile actomyosin networks consist of F-actin bundle and meshwork architectures, implicating the existence of different F-actin microstructures and corresponding nucleators. Here, Rac1 and the Scar/WAVE-Arp2/3 complex (branched F-actin nucleator), exhibiting constant levels, are necessary to support F-actin pulsation, whereas pulses of Dia (unbranched F-actin nucleator) trigger F-actin pulsation. The pulsatile F-actin networks recruit the F-actin turnover regulator cofilin, thus generating cofilin pulses. Cofilin at relatively low concentration can cooperate with F-actin nucleators to amplify F-actin and enhance its pulsation, while cofilin at relatively high concentration might trigger the F-actin disassembly to attenuate its pulsation. These two different effects of cofilin on F-actin pulsation were confirmed by Zdk-cofilin optogenetics. Rac1 signaling, Dia, and cofilin are also crucial for F-actin pulses in border cell migration. Our findings thus reveal a coordinated regulation of F-actin pulses conferring actomyosin contractility in morphogenesis and cell migration.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "Hao Li"
    },
    {
      "name": "Bing Liu"
    },
    {
      "name": "Jiaying Liu"
    },
    {
      "name": "Thomas Mangeat"
    },
    {
      "name": "Karine Belguise"
    },
    {
      "name": "Shi-Lei Xue"
    },
    {
      "name": "Xiaobo Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1xphmxdtn0z90.bib",
  "cited_by": 0,
  "doi": "10.1073/pnas.2530056123",
  "fulltext_url": null,
  "id": "1xphmxdtn0z90",
  "issns": [
    "0027-8424",
    "1091-6490"
  ],
  "landing_url": "https://hal.science/hal-05852845v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1307|Cellular Mechanics and Interactions"
    ]
  ],
  "openalex": "W7211966448",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-08",
  "publisher": "National Academy of Sciences",
  "ris": "https://research.draconitic.com/paper/1xphmxdtn0z90.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T12:20:13Z",
      "native_id": "hal-05852845",
      "source": "hal",
      "url": "https://hal.science/hal-05852845v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1307|Cellular Mechanics and Interactions",
      "subfield": "cell-biology"
    }
  ],
  "title": "Coordinated regulation of diverse F-actin organizations orchestrates F-actin pulses in the actomyosin network",
  "title_text": "Coordinated regulation of diverse F-actin organizations orchestrates F-actin pulses in the actomyosin network",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:20:25Z",
  "url": "https://research.draconitic.com/paper/1xphmxdtn0z90",
  "venue": "Proceedings of the National Academy of Sciences of the United States of America",
  "versions": []
}