{
  "abstract": "Chronic chikungunya disease is caused by the mosquito-borne chikungunya virus (CHIKV) induced by viral persistence in target tissues. To investigate the risk of viral persistence of the approved live-attenuated vaccine IXCHIQ® (VLA1553), cynomolgus macaques received a 100-fold higher dose than the approved dose for IXCHIQ® or wild-type CHIKV. In VLA1553-treated NHPs, fever was transient, coinciding with peak viremia, with no significant virus detected in tissues except for immune organs. WT CHIKV-treated NHPs developed fever persisting for several days with higher peak viremias, and virus was consistently detected in tissues at higher levels than in VLA1553-treated animals. Additionally, WT CHIKV-treated NHPs showed more CHIKV in saliva and vaginal fluid, lymphocytopenia, increased liver enzymes and plasma prostaglandin E₂, and higher expression of pro-inflammatory cytokines and chemokines associated with WT CHIKV disease than VLA1553-treated animals. This study demonstrated attenuation of vaccine strain VLA1553, with no critical observations in non-human primates (NHPs) following administration of a high dose.",
  "abstract_shown": true,
  "affiliations": [
    "Center for Immunology of Viral, Auto-Immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, INSERM, CEA, Fontenay-aux-Roses, France.",
    "Institut Pasteur de Guinée, Conakry, Guinea.",
    "Valneva Austria GmbH, Vienna, Austria. andrea.fritzer@valneva.com.",
    "Valneva Austria GmbH, Vienna, Austria."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Pierre Roques"
    },
    {
      "affs": [
        2
      ],
      "name": "Andrea Fritzer"
    },
    {
      "affs": [
        0
      ],
      "name": "Nathalie Dereuddre-Bosquet"
    },
    {
      "affs": [
        0
      ],
      "name": "Laetitia Bossevot"
    },
    {
      "affs": [
        0
      ],
      "name": "Quentin Pascal"
    },
    {
      "affs": [
        0
      ],
      "name": "Roger Le Grand"
    },
    {
      "affs": [
        3
      ],
      "name": "Urban Lundberg"
    },
    {
      "affs": [
        3
      ],
      "name": "Andreas Meinke"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1xzzgcrtsnx1s.bib",
  "cited_by": 0,
  "doi": "10.1038/s41541-026-01535-4",
  "fulltext_url": "https://europepmc.org/articles/PMC13687089",
  "id": "1xzzgcrtsnx1s",
  "issns": [
    "2059-0105"
  ],
  "landing_url": "https://europepmc.org/article/MED/42907477",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC254-282"
    ],
    [
      "lcc",
      "RC581-607"
    ],
    [
      "openalex",
      "2739|Mosquito-borne diseases and control"
    ]
  ],
  "openalex": "W7170142146",
  "pdf_url": "https://europepmc.org/articles/PMC13687089?pdf=render",
  "pmcid": "PMC13687089",
  "pmid": "42907477",
  "published": "2026-07-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/1xzzgcrtsnx1s.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:59Z",
      "native_id": "MED:42907477",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42907477"
    },
    {
      "first_seen": "2026-10-30T13:45:34Z",
      "native_id": "693934f51d5e47cdbcaf9b2535c6e4b8",
      "source": "doaj",
      "url": "https://doi.org/10.1038/s41541-026-01535-4"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Mosquito-borne diseases and control",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Limited tissue persistence confirms attenuation of live-attenuated chikungunya vaccine VLA1553 in non-human primates.",
  "title_text": "Limited tissue persistence confirms attenuation of live-attenuated chikungunya vaccine VLA1553 in non-human primates.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:34Z",
  "url": "https://research.draconitic.com/paper/1xzzgcrtsnx1s",
  "venue": "NPJ vaccines",
  "versions": []
}