{
  "abstract": "Acute gastrointestinal injury (AGI) remains a major complication after cardiopulmonary bypass, yet its microbiome-related determinants are unclear. We identify microbiota-mediated naringenin (NAR) release as a candidate modulator of AGI susceptibility. Patients who subsequently develop AGI have lower preoperative fecal NAR levels and β-glucuronidase (GUS) activity, accompanied by reduced abundance of Bacteroides vulgatus (B. vulgatus). In germ-free and conventional mice, B. vulgatus alleviates intestinal ischemia-reperfusion injury through GUS-dependent release of NAR from its glucuronide conjugate. Mechanistically, NAR engages the TLR4/MyD88-SPRR2A axis to suppress CHAC1-driven ferroptosis, thereby maintaining epithelial integrity and promoting mucosal repair in vivo and in organoids. Clinically, preoperative fecal NAR concentration and GUS activity show exploratory value as noninvasive markers for postoperative AGI risk stratification. Collectively, these findings support a microbiota-host metabolic model in which microbial NAR release may mitigate postoperative gastrointestinal injury by restricting ferroptosis, with potential implications for risk assessment and therapeutic modulation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China",
    "Guangdong Provincial Key Laboratory of Precision Anesthesia and Perioperative Organ Protection, Guangzhou, Guangdong, China",
    "Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China",
    "Shenzhen Key Laboratory of Gastrointestinal Microbiota and Disease, Department of Gastroenterology, Gynecology and Obstetrics, and Laboratory Medicine, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China",
    "State Key Laboratory of Multi-organ Injury Prevention and Treatment, Southern Medical University, Guangzhou, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Fan Deng"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jingjuan Hu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yue Min"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Sun Xie"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Zebin Lin"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Qishun Sun"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Huamin Liu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Shiying He"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Siyuan Feng"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ling Wu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xiaofeng Chen"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Linghong Xu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Zheang Zhang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Wenqi Tang"
    },
    {
      "affs": [
        2
      ],
      "name": "Zhuang Li"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Hongwei Zhou"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Kexuan Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1y5mfrknnjkmx.bib",
  "cited_by": 0,
  "doi": "10.1016/j.xcrm.2026.103101",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710387/",
  "id": "1y5mfrknnjkmx",
  "issns": [
    "2666-3791"
  ],
  "landing_url": "https://doi.org/10.1016/j.xcrm.2026.103101",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2740|Ferroptosis and cancer prognosis"
    ]
  ],
  "openalex": "W7220964873",
  "pdf_url": null,
  "pmcid": "PMC13710387",
  "pmid": "42849446",
  "published": "2026-10-08",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/1y5mfrknnjkmx.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:22Z",
      "native_id": "PMC13710387",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.xcrm.2026.103101"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Ferroptosis and cancer prognosis",
      "subfield": "general"
    }
  ],
  "title": "Microbiota-mediated naringenin release limits postoperative acute gastrointestinal injury by suppressing ferroptosis",
  "title_text": "Microbiota-mediated naringenin release limits postoperative acute gastrointestinal injury by suppressing ferroptosis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:22Z",
  "url": "https://research.draconitic.com/paper/1y5mfrknnjkmx",
  "venue": "Cell Reports Medicine",
  "versions": []
}