{
  "abstract": "BACKGROUND: Diagnosing myocardial infarction in patients with prior coronary artery bypass grafting (CABG) remains challenging, primarily because of lower diagnostic accuracy of high-sensitivity cardiac troponin (hs-cTn). cMyC (cardiac myosin-binding protein C), because of its faster release kinetics and greater abundance, may offer improved diagnostic performance in this population. METHODS: The diagnostic accuracy of cMyC was directly compared with that of hs-cTnT and hs-cTnI in a prospective, international, multicenter, diagnostic study enrolling adult patients presenting to the emergency department with acute chest discomfort. Final diagnoses were centrally adjudicated by 2 independent cardiologists using all available clinical and study-specific data, including imaging and serial hs-cTnT measurements. Patients were stratified according to the presence or absence of prior CABG. RESULTS: <0.001). In the CABG group, the diagnostic accuracy of cMyC as quantified by the area under the curve was 0.88 (95% CI, 0.85-0.92), which was comparable but not superior to that of hs-cTnT (0.89 [95% CI, 0.86-0.92]) and hs-cTnI (0.88 [95% CI, 0.84-0.91]). These findings were consistent across alternative high-sensitivity cMyC assays. CONCLUSIONS: In patients with prior CABG, cMyC demonstrated high diagnostic accuracy for myocardial infarction, but not superior to established hs-cTnT and hs-cTnI assays. REGISTRATION: URL: clinicaltrials.gov; Unique Identifier: NCT00470587.",
  "abstract_shown": true,
  "affiliations": [
    "University Hospital Basel, University of Basel",
    "GREAT Network",
    "University Hospital Zurich, University of Zurich",
    "University of Turin",
    "University of Barcelona",
    "Kantonsspital Luzern",
    "University Hospital Zurich",
    "Hospital Clínico San Carlos",
    "Medical University of Katowice",
    "Kantonsspital Liestal",
    "University of Edinburgh"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 52,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Rebekka Odermatt",
      "orcid": "0009-0009-5934-0062"
    },
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      "affs": [
        0,
        1,
        2
      ],
      "name": "Luca Koechlin",
      "orcid": "0000-0002-2929-8600"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Pedro Lopez‐Ayala",
      "orcid": "0000-0002-7787-0640"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Emel Kaplan",
      "orcid": "0009-0004-0536-6922"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Lourdes Herraiz Recuenco"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Gabrielle Huré",
      "orcid": "0009-0006-6022-8850"
    },
    {
      "affs": [
        0,
        1,
        3
      ],
      "name": "Paolo Bima"
    },
    {
      "affs": [
        0
      ],
      "name": "Luca Crisanti",
      "orcid": "0000-0003-4309-5751"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Karin Wildi",
      "orcid": "0000-0002-6520-2696"
    },
    {
      "affs": [
        2,
        4
      ],
      "name": "Òscar Miró",
      "orcid": "0000-0002-7924-9751"
    },
    {
      "affs": [
        5
      ],
      "name": "Michael Christ",
      "orcid": "0000-0001-7977-0195"
    },
    {
      "affs": [
        6
      ],
      "name": "Dagmar I. Keller",
      "orcid": "0009-0001-9423-3635"
    },
    {
      "affs": [
        7
      ],
      "name": "Javier F. Martin‐Sanchez",
      "orcid": "0000-0002-5970-725X"
    },
    {
      "affs": [
        8
      ],
      "name": "Beata Morawiec",
      "orcid": "0000-0002-0187-1364"
    },
    {
      "affs": [
        1,
        9
      ],
      "name": "Nicolas Geigy",
      "orcid": "0000-0001-6639-1444"
    },
    {
      "affs": [
        0
      ],
      "name": "Felix Mahfoud",
      "orcid": "0000-0002-4425-549X"
    },
    {
      "affs": [
        2
      ],
      "name": "Hector Rodriguez Cetina Biefer",
      "orcid": "0000-0002-5855-8993"
    },
    {
      "affs": [
        2
      ],
      "name": "Omer Dzemali",
      "orcid": "0000-0001-7910-5152"
    },
    {
      "affs": [
        0,
        1,
        10
      ],
      "name": "Jasper Boeddinghaus",
      "orcid": "0000-0003-4404-4956"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ivo Strebel",
      "orcid": "0000-0001-9976-4112"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Christian Mueller",
      "orcid": "0000-0002-1120-6405"
    },
    {
      "name": "Carlos Spagnuolo"
    },
    {
      "name": "Jonas Glaeser"
    },
    {
      "name": "Thomas Nestelberger"
    },
    {
      "name": "Desiree Wussler"
    },
    {
      "name": "Maria Rubini Gimenez"
    },
    {
      "name": "Tobias Zimmermann"
    },
    {
      "name": "Jude Formambuh"
    },
    {
      "name": "Danielle M. Gualandro"
    },
    {
      "name": "Christian Puelacher"
    },
    {
      "name": "Jeanne du Fay de Lavallaz"
    },
    {
      "name": "Koray Durak"
    },
    {
      "name": "Arnaud Champetier"
    },
    {
      "name": "Julia Reinhardt"
    },
    {
      "name": "Kathrin Meissner"
    },
    {
      "name": "Katharina Rentsch"
    },
    {
      "name": "Andreas Buser"
    },
    {
      "name": "Ksenia Slankamenac"
    },
    {
      "name": "Beatriz López"
    },
    {
      "name": "Gemma Martinez‐Nadal"
    },
    {
      "name": "Esther Rodriguez Adrada"
    },
    {
      "name": "Damian Kawecki"
    },
    {
      "name": "Piotr Muzyk"
    },
    {
      "name": "Beatriz López"
    },
    {
      "name": "Gemma Martinez‐Nadal"
    },
    {
      "name": "Esther Rodriguez Adrada"
    },
    {
      "name": "Joanna Gawinecka"
    },
    {
      "name": "Damian Kawecki"
    },
    {
      "name": "Piotr Muzyk"
    },
    {
      "name": "Eliška Potluková"
    },
    {
      "name": "Stephan Steuer"
    },
    {
      "name": "Angelika Hammerer‐Lercher"
    }
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  "bibtex": "https://research.draconitic.com/paper/1y5nypndmc975.bib",
  "cited_by": 0,
  "doi": "10.1161/jaha.126.049244",
  "fulltext_url": null,
  "id": "1y5nypndmc975",
  "issns": [
    "2047-9980"
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  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2705|Acute Myocardial Infarction Research"
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  "openalex": "W7221330587",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-20",
  "publisher": "Ovid Technologies (Wolters Kluwer Health)",
  "ris": "https://research.draconitic.com/paper/1y5nypndmc975.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:28Z",
      "native_id": "10.1161/jaha.126.049244",
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      "url": "https://www.ahajournals.org/doi/10.1161/JAHA.126.049244"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Acute Myocardial Infarction Research",
      "subfield": "cardiovascular"
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  ],
  "title": "Cardiac Myosin‐Binding Protein C for Diagnosis of Myocardial Infarction in Patients With Prior Coronary Artery Bypass Grafting",
  "title_text": "Cardiac Myosin‐Binding Protein C for Diagnosis of Myocardial Infarction in Patients With Prior Coronary Artery Bypass Grafting",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:28Z",
  "url": "https://research.draconitic.com/paper/1y5nypndmc975",
  "venue": "Journal of the American Heart Association",
  "versions": []
}