{
  "abstract": "Developing more sustainable, efficient and environmentally benign protocols towards the construction of promising heterocycles remains a cornerstone of green and sustainable medicinal chemistry. Herein, a two-stage, microwave-assisted, rapid and greener synthesis of 6,7-dimethoxy-2-aryl-4-aminosubstituted-quinazoline derivatives is demonstrated. Chemoselective SNAr at C-4 position of 2,4-dichloro-6,7-dimethoxyquinazoline with primary amines in bio-renewable γ-valerolactone (GVL) solvent delivered 4-amino-2-chloroquinazoline intermediates. Subsequently, a palladium-catalyzed Suzuki–Miyaura cross-coupling at C-2 using ethanol–water (9 : 1) as an eco-friendly medium under microwave irradiation at 100 °C for 120 min, furnished 2-aryl-4-aminosubstituted quinazoline derivatives. Relative to a conventional solvent benchmark for step 2, the optimized platform achieves a 4.8-fold reduction in reaction-step simple E-factor reduction from 18.4 to 3.8 kg kg−1, enhancement in reaction-step process mass intensity to 5.2-fold (8.2 g g−1) from 42.6 g g−1, 80% reduction in reaction time (120 from 480–840 minutes) and achieving an Intrinsic atom economy of 82.2%, addressing seven out of the twelve Anastas–Warner green chemistry principles. This workflow underscores a scalable, solvent-efficient, metal-catalyzed route with reduced environmental impact.",
  "abstract_shown": true,
  "affiliations": [
    "Sigma Aldrich Chemicals Pvt Ltd #12, Bommasandra-Jigani Link Road Bangalore-560100 India",
    "Centre for Nano and Material Sciences, JAIN (deemed-to-be) University Jain Global Campus, Kanakapura Road Bangalore-562112 India",
    "Department of Chemistry, School of Basic and Applied Sciences, SGT University Gurugram-122505 Haryana India",
    "Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University P. O. Box 84428 Riyadh 11671 Saudi Arabia"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Rhushikesh C. Deokar",
      "orcid": "0009-0007-3353-3160"
    },
    {
      "affs": [
        0
      ],
      "name": "Thrilokraj R"
    },
    {
      "affs": [
        2
      ],
      "name": "Nutan Sharma"
    },
    {
      "affs": [
        1
      ],
      "name": "Dhananjay Satav"
    },
    {
      "affs": [
        0
      ],
      "name": "Markus Obkircher"
    },
    {
      "affs": [
        3
      ],
      "name": "Sadaf Jamal Gilani"
    },
    {
      "affs": [
        0
      ],
      "name": "Saikat Sinha"
    },
    {
      "affs": [
        1
      ],
      "name": "Ramesh B. Dateer",
      "orcid": "0000-0002-1573-5259"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1y6rjdg66vzt3.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra08343a",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13729383/?tool=EBI",
  "id": "1y6rjdg66vzt3",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13729383",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1605|Quinazolinone synthesis and applications"
    ]
  ],
  "openalex": "W7225196071",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13729383/pdf/?tool=EBI",
  "pmcid": "PMC13729383",
  "pmid": "42979059",
  "published": "2026-11-03",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/1y6rjdg66vzt3.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:46Z",
      "native_id": "PMC:PMC13729383",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13729383"
    },
    {
      "first_seen": "2026-11-07T12:22:09Z",
      "native_id": "PMC13729383",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra08343a"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Quinazolinone synthesis and applications",
      "subfield": "organic"
    }
  ],
  "title": "Greener and more sustainable access to 6,7-dimethoxy-2-aryl-4-aminoquinazolines via microwave-assisted chemo-selective synthesis in bio-renewable solvents",
  "title_text": "Greener and more sustainable access to 6,7-dimethoxy-2-aryl-4-aminoquinazolines via microwave-assisted chemo-selective synthesis in bio-renewable solvents",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:09Z",
  "url": "https://research.draconitic.com/paper/1y6rjdg66vzt3",
  "venue": "RSC advances",
  "versions": []
}