{
  "abstract": "Conventional dendritic cells (cDCs) are key sentinels at epithelial barriers, regulating immunity to microbial pathogens and commensals while preserving tissue integrity. NOTCH2 deficiency in CD11c-expressing cells ( Notch2 cKO ) disrupts type 2a DC (cDC2a) development, impairs intestinal T H 17 immunity and increases susceptibility to enteropathogenic bacteria. This defect leads to persistent dysbiosis in Notch2 cKO mice, characterized by low-grade inflammation and systemic autoimmune features, including elevated autoantibody titers and renal immune complex deposition. Dysbiosis precedes expansion of highly inflammatory AXL-expressing type 3 DCs (AXL + inf-DC3), promoting chronic inflammation and tertiary lymphoid structures driving adaptive immune responses. Notably, dysbiosis is defined by three dominant pathobionts and is transferable to wild-type mice, recapitulating the autoimmune features observed in Notch2 cKO mice. Here these findings identify a microbiota–DC axis linking intestinal pathobionts to systemic autoimmunity, establishing inflammatory DC3 as the cellular bridge between dysbiosis, chronic inflammation and autoimmune pathogenesis.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 35,
  "authors": [
    {
      "name": "Grozdan Cvijetic"
    },
    {
      "name": "Valentina Ottaviani"
    },
    {
      "name": "Isabella Conway"
    },
    {
      "name": "Erfan Jabari"
    },
    {
      "name": "Mladen Mitrovic"
    },
    {
      "name": "Haiting Wang"
    },
    {
      "name": "Patrick Fernandes Rodrigues"
    },
    {
      "name": "Anastasia Du Halgouet"
    },
    {
      "name": "Siqi Zhao"
    },
    {
      "name": "Harrison Wang"
    },
    {
      "name": "Anjali Chandroth"
    },
    {
      "name": "Robert Palmer"
    },
    {
      "name": "Eduard Ansaldo"
    },
    {
      "name": "Andrew Doyle"
    },
    {
      "name": "Daniel Martin"
    },
    {
      "name": "Roman Szabo"
    },
    {
      "name": "Cristina Corsino"
    },
    {
      "name": "Francesca Pala"
    },
    {
      "name": "Miriam Fernandes"
    },
    {
      "name": "Nicolas Bouladoux"
    },
    {
      "name": "Howard Young"
    },
    {
      "name": "Yufan Zheng"
    },
    {
      "name": "Zhaoyuan Liu"
    },
    {
      "name": "Florent Ginhoux"
    },
    {
      "name": "Eric Dang"
    },
    {
      "name": "Stephen Darnell"
    },
    {
      "name": "George Liechti"
    },
    {
      "name": "Michail Lionakis"
    },
    {
      "name": "Robert Ivanek"
    },
    {
      "name": "Luigi Notarangelo"
    },
    {
      "name": "Yasmine Belkaid"
    },
    {
      "name": "Wanjun Chen"
    },
    {
      "name": "Amiran Dzutsev"
    },
    {
      "name": "Giorgio Trinchieri"
    },
    {
      "name": "Roxane Tussiwand"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1y7eqc64p1qb2.bib",
  "cited_by": 1,
  "doi": "10.1038/s41590-026-02599-z",
  "fulltext_url": null,
  "id": "1y7eqc64p1qb2",
  "issns": [
    "1529-2908",
    "1529-2916"
  ],
  "landing_url": "https://pasteur.hal.science/pasteur-05741356v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.imm"
    ],
    [
      "hal",
      "2.sdv.imm.ii"
    ],
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7169880109",
  "pdf_url": "https://pasteur.hal.science/pasteur-05741356/document",
  "pmcid": null,
  "pmid": "42481649",
  "published": "2026-07-21",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/1y7eqc64p1qb2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:29Z",
      "native_id": "pasteur-05741356",
      "source": "hal",
      "url": "https://pasteur.hal.science/pasteur-05741356v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.imm",
      "subfield": "immunology"
    }
  ],
  "title": "Dysbiosis-induced expansion of AXL-positive inflammatory type 3 dendritic cells triggers preclinical autoimmunity",
  "title_text": "Dysbiosis-induced expansion of AXL-positive inflammatory type 3 dendritic cells triggers preclinical autoimmunity",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:29Z",
  "url": "https://research.draconitic.com/paper/1y7eqc64p1qb2",
  "venue": "Nature Immunology",
  "versions": []
}