{
  "abstract": "Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder primarily characterized by progressive cognitive dysfunction. Substantial loss of hippocampal neurons is closely associated with irreversible cognitive decline; however, the underlying mechanisms have not yet been fully elucidated. In this study, conditionally overexpressing adiponectin receptor 1 (AdipoR1) in the hippocampus of APP/PS1 transgenic AD mice, we found that it significantly improved learning and memory abilities and effectively mitigated the abnormal loss of hippocampal neurons and dendritic spines. AdipoR1 overexpression primarily maintained neuronal numbers through reducing neuronal death rather than promoting neurogenesis, and this protective effect is closely linked to the inhibition of the neuronal NLRP3 inflammasome, leading to a marked reduction in pyroptosis levels within the hippocampus. Our results demonstrated, for the first time, that AdipoR1 exerted a crucial neuroprotective role in AD pathology through modulating the NLRP3-mediated neuroinflammatory pathway, which might offer new insights into the mechanisms of neuronal loss in AD and suggest that the AdipoR1–NLRP3 signaling axis may serve as a potential therapeutic target for early intervention in AD.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Histology and Embryology, College of Basic Medicine, Chongqing Medical University, Chongqing, China",
    "Lab Teaching & Management Center, Chongqing Medical University, Chongqing, China",
    "Laboratory of Stem Cells and Tissue Engineering, College of Basic Medicine, Chongqing Medical University, Chongqing, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Chunnian Hu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jing Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Lin Jiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuning Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuhui Deng"
    },
    {
      "affs": [
        0
      ],
      "name": "Qing Pan"
    },
    {
      "affs": [
        0
      ],
      "name": "Shun Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenyu Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Lei Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Fenglei Chao"
    },
    {
      "affs": [
        2
      ],
      "name": "Yanmin Luo"
    },
    {
      "affs": [
        0
      ],
      "name": "Jing Tang"
    },
    {
      "affs": [
        2
      ],
      "name": "Qian Xiao"
    },
    {
      "affs": [
        2
      ],
      "name": "Xin Liang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yingqiang Qi"
    },
    {
      "affs": [
        0
      ],
      "name": "Yong Tang"
    },
    {
      "affs": [
        0
      ],
      "name": "Chunni Zhou"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1ycsxbw1wkdrk.bib",
  "cited_by": 0,
  "doi": "10.1016/j.neurot.2026.e01093",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13722108/?tool=EBI",
  "id": "1ycsxbw1wkdrk",
  "issns": [
    "1933-7213",
    "1878-7479"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13722108",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2737|Alzheimer's disease research and treatments"
    ]
  ],
  "openalex": "W7223551558",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13722108/pdf/?tool=EBI",
  "pmcid": "PMC13722108",
  "pmid": "42933063",
  "published": "2026-10-26",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/1ycsxbw1wkdrk.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:37Z",
      "native_id": "PMC:PMC13722108",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13722108"
    },
    {
      "first_seen": "2026-11-03T12:22:40Z",
      "native_id": "PMC13722108",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.neurot.2026.e01093"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Alzheimer's disease research and treatments",
      "subfield": "physiology"
    }
  ],
  "title": "Overexpression of hippocampal AdipoR1 ameliorates cognitive dysfunction in APP/PS1 mice through inhibiting NLRP3-Mediated neuronal pyroptosis",
  "title_text": "Overexpression of hippocampal AdipoR1 ameliorates cognitive dysfunction in APP/PS1 mice through inhibiting NLRP3-Mediated neuronal pyroptosis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:40Z",
  "url": "https://research.draconitic.com/paper/1ycsxbw1wkdrk",
  "venue": "Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics",
  "versions": []
}