{
  "abstract": "Objective\n\nThe triglyceride-glucose (TyG) index is an easily accessible novel indicator of insulin resistance. This study aimed to investigate the relationship between the TyG index and the homeostatic model assessment of insulin resistance (HOMA-IR) in patients with primary hyperparathyroidism (PHPT), compare these parameters with healthy controls, and evaluate whether the TyG index could serve as a potential new parameter in patients undergoing parathyroidectomy.Methods\n\nWe retrospectively analyzed PHPT patients diagnosed between October 2023 and May 2024 in a tertiary endocrinology clinic. TyG index and HOMA-IR were compared with age- and sex-matched healthy controls, and subgroup analyses were performed for parathyroidectomy status. Statistical tests included correlation analysis and ROC curves.Results\n\nHOMA-IR, TyG index and HbA1c were higher in patients with hyperparathyroidism compared to the control group (p < 0.001). The area under the curve (AUC) of each curve was calculated. It was found that serum calcium (AUC: 0.910, 95% CI: 0.849-0.971), fasting serum insulin (AUC: 0.876, 95% CI: 0.799-0.953), HOMA (AUC: 0.877, 95% CI: 0.799-0.956) and TyG index (AUC: 0.859, 95% CI: 0.777-0.941) demonstrated a satisfactory diagnostic capacity, with serum calcium achieving the highest score. ROC analysis demonstrated high diagnostic performance of TyG index (AUC = 0.859, cut-off = 9.6, sensitivity 82.9%, specificity 73.0%) and HOMA-IR (AUC = 0.877, cut-off = 2.69, sensitivity 84.2%, specificity 76.3%).Conclusions\n\nThe TyG index (cut-off = 9.6) reliably identified PHPT patients requiring parathyroidectomy and may serve as a simple surrogate marker of insulin resistance.Clinical trial number\n\nNot applicable.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Endocrinology and Metabolism, Gaziantep City Hospital, Gaziantep, Turkey. dr.ilkcan_33@hotmail.com.",
    "Department of Endocrinology and Metabolism, Gaziantep City Hospital, Gaziantep, Turkey.",
    "Department of Endocrinology and Metabolism, Faculty of Medicine, Gaziantep Islam Science and Technology University, Gaziantep, Turkey."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "İlkcan Çerçi Koçar",
      "orcid": "0000-0002-8047-4956"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Neşe Bülbül",
      "orcid": "0000-0002-6990-4337"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1ye0bx73pfxbb.bib",
  "cited_by": 0,
  "doi": "10.1186/s12902-026-02495-5",
  "fulltext_url": "https://europepmc.org/articles/PMC13685237",
  "id": "1ye0bx73pfxbb",
  "issns": [
    "1472-6823"
  ],
  "landing_url": "https://europepmc.org/article/MED/42907831",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC648-665"
    ],
    [
      "openalex",
      "2727|Parathyroid Disorders and Treatments"
    ]
  ],
  "openalex": "W7203896476",
  "pdf_url": "https://europepmc.org/articles/PMC13685237?pdf=render",
  "pmcid": "PMC13685237",
  "pmid": "42907831",
  "published": "2026-08-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/1ye0bx73pfxbb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:57Z",
      "native_id": "MED:42907831",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42907831"
    },
    {
      "first_seen": "2026-10-30T13:46:03Z",
      "native_id": "7dc77bba04254a8c9d1953768f551ccd",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s12902-026-02495-5"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RC648-665",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Role of the triglyceride-glucose index in predicting parathyroidectomy in primary hyperparathyroidism.",
  "title_text": "Role of the triglyceride-glucose index in predicting parathyroidectomy in primary hyperparathyroidism.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:03Z",
  "url": "https://research.draconitic.com/paper/1ye0bx73pfxbb",
  "venue": "BMC endocrine disorders",
  "versions": []
}