{
  "abstract": "Circulating tumor DNA-based molecular residual disease (ctDNA-MRD) provides prognostic information in early breast cancer, but its detection performance and clinical interpretation differ across molecular subtypes. This review examines subtype-specific ctDNA clearance, molecular re-emergence, and implications for neoadjuvant response assessment, postoperative surveillance, and MRD-directed trials. In ER-positive/HER2-negative disease, low shedding and late recurrence limit the negative predictive value of a single negative result, while the clinical utility of extended monitoring remains unproven. In HER2-positive disease, rapid clearance during neoadjuvant therapy may complement pathological complete response and residual cancer burden but does not independently determine adjuvant treatment. In triple-negative breast cancer, higher detectability and early recurrence strengthen the association between persistent or re-emergent ctDNA and short-term relapse risk. Across subtypes, ctDNA-MRD should complement clinicopathological and imaging assessment rather than independently guide treatment. Standardized assays and randomized intervention trials are required before routine clinical implementation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Breast Surgery, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, Gansu Province, China.",
    "Department of Breast Surgery, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, Gansu Province, China. tspb510@sina.com."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Fuzhi Jiao"
    },
    {
      "affs": [
        0
      ],
      "name": "Xueyan Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Rong Shi"
    },
    {
      "affs": [
        0
      ],
      "name": "Xueqian Feng"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaocheng Cheng"
    },
    {
      "affs": [
        0
      ],
      "name": "Mingxuan Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Bin Pan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1yfxdg6z9ahny.bib",
  "cited_by": 0,
  "doi": "10.1186/s12957-026-04518-w",
  "fulltext_url": "https://europepmc.org/articles/PMC13721233",
  "id": "1yfxdg6z9ahny",
  "issns": [
    "1477-7819"
  ],
  "landing_url": "https://europepmc.org/article/MED/42958365",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "1306|Cancer Genomics and Diagnostics"
    ]
  ],
  "openalex": "W7172353112",
  "pdf_url": "https://europepmc.org/articles/PMC13721233?pdf=render",
  "pmcid": "PMC13721233",
  "pmid": "42958365",
  "published": "2026-08-03",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/1yfxdg6z9ahny.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:47Z",
      "native_id": "MED:42958365",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42958365"
    },
    {
      "first_seen": "2026-11-03T12:21:57Z",
      "native_id": "PMC13721233",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12957-026-04518-w"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Cancer Genomics and Diagnostics",
      "subfield": "oncology"
    }
  ],
  "title": "Dynamic ctDNA-MRD in breast cancer: subtype-specific implications for perioperative decision-making, postoperative surveillance, and MRD-guided therapy.",
  "title_text": "Dynamic ctDNA-MRD in breast cancer: subtype-specific implications for perioperative decision-making, postoperative surveillance, and MRD-guided therapy.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:57Z",
  "url": "https://research.draconitic.com/paper/1yfxdg6z9ahny",
  "venue": "World journal of surgical oncology",
  "versions": []
}