{
  "abstract": "It was previously observed that partial regrowth can be induced to begin in adult Drosophila limb by modulating nutrients. In this work, to further investigate this observation, we characterized the early cellular- and tissue-level processes that are promoted by nutrient treatment after injury. We find that response to nutrient treatment can be readily identified within hours, by alteration in wound healing. Subsequently, at day scale, dramatic reversal of large-scale tissue loss occurs in treated flies. Finally, at week scale, tissue remodeling begins, and a dome-shaped protrusion forms at the injury site. Using single-nucleus RNA sequencing at this stage, we find widespread transcriptional modulations across cell types. Distinct muscle and epithelial cell types emerge that are enriched in mitotic and morphogenetic genes, including those associated with regeneration in larval tissues. These tissue-, cell-, and gene-level processes characterized here provide a framework for the previously observed partial limb growth and for further investigating the suggestion of regeneration induction in adult Drosophila through nutrient treatment.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA",
    "Department of Computing and Mathematical Sciences, California Institute of Technology, Pasadena, CA 91125, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yutian Li",
      "orcid": "0000-0001-8151-3518"
    },
    {
      "affs": [
        0
      ],
      "name": "Jesus del Rio Salgado"
    },
    {
      "affs": [
        0
      ],
      "name": "Gloria Bates"
    },
    {
      "affs": [
        0
      ],
      "name": "Zevin J. Condiotte"
    },
    {
      "affs": [
        0
      ],
      "name": "Maya Caskey"
    },
    {
      "affs": [
        0
      ],
      "name": "Christian M. Dimayuga"
    },
    {
      "affs": [
        0
      ],
      "name": "Brian Williams"
    },
    {
      "affs": [
        0
      ],
      "name": "Ingileif Hallgrimsdottir"
    },
    {
      "affs": [
        1
      ],
      "name": "Lior Pachter"
    },
    {
      "affs": [
        0
      ],
      "name": "Lea Goentoro"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1yn5qtkhbs6ww.bib",
  "cited_by": 1,
  "doi": "10.1242/bio.062737",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13730125/",
  "id": "1yn5qtkhbs6ww",
  "issns": [
    "2046-6390"
  ],
  "landing_url": "https://doi.org/10.1242/bio.062737",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "1312|Planarian Biology and Electrostimulation"
    ]
  ],
  "openalex": "W7206160434",
  "pdf_url": null,
  "pmcid": "PMC13730125",
  "pmid": "42802989",
  "published": "2026-10-23",
  "publisher": "Company of Biologists",
  "ris": "https://research.draconitic.com/paper/1yn5qtkhbs6ww.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:22:45Z",
      "native_id": "PMC13730125",
      "source": "pmc",
      "url": "https://doi.org/10.1242/bio.062737"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Planarian Biology and Electrostimulation",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Early injury responses to nutrient treatment in adult Drosophila limb",
  "title_text": "Early injury responses to nutrient treatment in adult Drosophila limb",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:45Z",
  "url": "https://research.draconitic.com/paper/1yn5qtkhbs6ww",
  "venue": "Biology Open",
  "versions": []
}