{
  "abstract": "Microbial constituents in the gastrointestinal tract, the urine and prostate tissue are being linked with clinical differences in prostate cancer, and a recent meta-analysis has linked periodontal disease to this cancer. Several hypotheses exist regarding how specific bacteria can contribute towards the development of prostate cancer. Recovering microbial genomes, and their genomic features, from clinical samples and investigating fine-scale taxonomy is a critical first step in investigating causality. Here, we describe the microbial diversity of samples associated with prostate cancer. Metagenomic assembly of non-human reads from the PanProstate Cancer Group, derived from blood, saliva samples and prostate tissue whole-genome data (N = 247), successfully reconstructed 249 highly complete bacterial genomes, predominantly from oral samples. Our data, reveals eighteen bacterial species from the oral cavity without species level classification, while demonstrating a wide range of known species. This approach enables us to gain additional insights of the microbes in cancer patients at no additional sequencing cost and has the potential to reveal new links that could improve our understanding of cancer initiation and development.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Metabolic Health, Norwich Medical School, University of East Anglia, University of East Anglia, Norwich, UK. A.Gihawi@uea.ac.uk.",
    "Ancestry and Health Genomics Laboratory, Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia. A.Gihawi@uea.ac.uk.",
    "Department of Metabolic Health, Norwich Medical School, University of East Anglia, University of East Anglia, Norwich, UK.",
    "Prostate Cancer Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.",
    "Wellcome Sanger Institute, Cambridge, UK.",
    "Department of Surgery, The University of Melbourne, Parkville, VIC, Australia.",
    "Department of Urology, Peninsula Health, Frankston, VIC, Australia.",
    "Division of Urology, Royal Melbourne Hospital, Parkville, VIC, Australia.",
    "The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.",
    "Department of Urology, Western Health, Footscray, VIC, Australia.",
    "Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark.",
    "Finsen Laboratory, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.",
    "Cambridge Prostate Cancer Research and Clinical Trials Group, University of Cambridge & Cambridge University Hospitals NHS Trust S2, Cambridge Biomedical Campus, Cambridge, UK.",
    "Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.",
    "Melbourne Bioinformatics, The University of Melbourne, Parkville, VIC, Australia.",
    "Royal Marsden NHS Foundation Trust, London, UK.",
    "The Institute of Cancer Research, London, UK.",
    "Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.",
    "The Broad Institute of Harvard and MIT, Cambridge, MA, USA.",
    "The New York Genome Center, New York, NY, USA.",
    "Computational Biology Program, Ontario Institute for Cancer Research (OICR), Toronto, ON, Canada.",
    "Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.",
    "Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.",
    "Manchester Cancer Research Centre, The University of Manchester, Manchester, UK.",
    "Department of Urology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.",
    "Jonsson Comprehensive Cancer Centere, University of California-Los Angeles, Los Angeles, CA, USA.",
    "Collaborative Centre for Genomic Cancer Medicine, The Victorian Comprehensive Cancer Centre, Parkville, VIC, Australia.",
    "Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, Australia.",
    "Australian BioCommons, The University of Melbourne, North Melbourne, VIC, Australia.",
    "Faculty of Medicine Nursing and Health Sciences, Department of Medicine, Central Clinical School, Monash University, Melbourne, VIC, Australia.",
    "Christie NHS Foundation Trust, Manchester, UK.",
    "Div Cancer Sciences, FBMH, University of Manchester, Manchester, UK.",
    "Manchester Cancer Research Centre and Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.",
    "Department of Biology, University of Konstanz, Konstanz, Germany.",
    "Princess Margaret Cancer Centre, University Health Network, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.",
    "Division of Cancer Sciences, The University of Manchester, Manchester, UK.",
    "Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.",
    "Department of Oncology, KU Leuven, Leuven, Belgium.",
    "Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia.",
    "Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 49,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "A Gihawi",
      "orcid": "0000-0002-3676-5561"
    },
    {
      "affs": [
        2
      ],
      "name": "A Bampalis"
    },
    {
      "affs": [
        2
      ],
      "name": "S Subramanian"
    },
    {
      "name": "Pan Prostate Cancer Group"
    },
    {
      "affs": [
        3
      ],
      "name": "G S Bova"
    },
    {
      "affs": [
        4
      ],
      "name": "A Butler"
    },
    {
      "affs": [
        5,
        6,
        7,
        8,
        9
      ],
      "name": "N M Corcoran"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "F Favero"
    },
    {
      "affs": [
        12
      ],
      "name": "V Gnanapragasam"
    },
    {
      "affs": [
        5,
        13
      ],
      "name": "A Hamid"
    },
    {
      "affs": [
        14
      ],
      "name": "C Jung"
    },
    {
      "affs": [
        15,
        16
      ],
      "name": "Z Kote Jarai"
    },
    {
      "affs": [
        4
      ],
      "name": "G Leeman"
    },
    {
      "affs": [
        17,
        18,
        19
      ],
      "name": "M Loda"
    },
    {
      "affs": [
        20,
        21,
        22
      ],
      "name": "J Reimand"
    },
    {
      "affs": [
        23
      ],
      "name": "A Sahli"
    },
    {
      "affs": [
        24
      ],
      "name": "T Schlomm"
    },
    {
      "affs": [
        25
      ],
      "name": "T N Yamaguchi"
    },
    {
      "affs": [
        10,
        11,
        24
      ],
      "name": "J Weischenfelft"
    },
    {
      "affs": [
        5,
        7,
        8,
        26,
        27
      ],
      "name": "C Hovens"
    },
    {
      "affs": [
        5,
        14,
        28,
        29
      ],
      "name": "B Pope"
    },
    {
      "affs": [
        30,
        31,
        32
      ],
      "name": "R Bristow"
    },
    {
      "affs": [
        16
      ],
      "name": "M N Brook"
    },
    {
      "affs": [
        20,
        21
      ],
      "name": "K C L Cheng"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "E G Girma"
    },
    {
      "affs": [
        33
      ],
      "name": "A J Gruber"
    },
    {
      "affs": [
        34
      ],
      "name": "H H He"
    },
    {
      "affs": [
        17
      ],
      "name": "E L Imada"
    },
    {
      "affs": [
        35
      ],
      "name": "G M Jakobsdottir"
    },
    {
      "affs": [
        17
      ],
      "name": "F Khani"
    },
    {
      "affs": [
        36,
        37
      ],
      "name": "P Lutsik"
    },
    {
      "affs": [
        17
      ],
      "name": "L Marchionni"
    },
    {
      "affs": [
        8,
        38
      ],
      "name": "R Molania"
    },
    {
      "affs": [
        8,
        38
      ],
      "name": "A T Papenfuss"
    },
    {
      "affs": [
        20
      ],
      "name": "D Pellegrina"
    },
    {
      "affs": [
        17
      ],
      "name": "L R Queiroz"
    },
    {
      "affs": [
        39
      ],
      "name": "T Rausch"
    },
    {
      "affs": [
        17
      ],
      "name": "B Robinson"
    },
    {
      "affs": [
        17
      ],
      "name": "C Zanettini"
    },
    {
      "name": "K D Sørensen"
    },
    {
      "name": "P Lamy"
    },
    {
      "name": "G Cancel-Tassin"
    },
    {
      "name": "O Cussenot"
    },
    {
      "affs": [
        15,
        16
      ],
      "name": "R A Eeles"
    },
    {
      "name": "N Annels"
    },
    {
      "affs": [
        2,
        23
      ],
      "name": "V M Hayes"
    },
    {
      "affs": [
        2
      ],
      "name": "R Hurst"
    },
    {
      "affs": [
        2
      ],
      "name": "C S Cooper"
    },
    {
      "affs": [
        2
      ],
      "name": "D S Brewer"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1z1hxy0jnp761.bib",
  "cited_by": 0,
  "doi": "10.1038/s41522-026-01140-2",
  "fulltext_url": "https://europepmc.org/articles/PMC13683340",
  "id": "1z1hxy0jnp761",
  "issns": [
    "2055-5008"
  ],
  "landing_url": "https://europepmc.org/article/MED/42901952",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QR100-130"
    ],
    [
      "openalex",
      "1312|Genomics and Phylogenetic Studies"
    ]
  ],
  "openalex": "W7223019595",
  "pdf_url": "https://europepmc.org/articles/PMC13683340?pdf=render",
  "pmcid": "PMC13683340",
  "pmid": "42901952",
  "published": "2026-10-20",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/1z1hxy0jnp761.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42901952",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42901952"
    },
    {
      "first_seen": "2026-10-30T13:45:48Z",
      "native_id": "c89e0c94a547472e9f7b46d714b7a998",
      "source": "doaj",
      "url": "https://doi.org/10.1038/s41522-026-01140-2"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Genomics and Phylogenetic Studies",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Recovering anaerobic bacterial genomes in saliva, tumour and blood whole genome sequencing data from patients with prostate cancer.",
  "title_text": "Recovering anaerobic bacterial genomes in saliva, tumour and blood whole genome sequencing data from patients with prostate cancer.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:48Z",
  "url": "https://research.draconitic.com/paper/1z1hxy0jnp761",
  "venue": "NPJ biofilms and microbiomes",
  "versions": []
}