{
  "abstract": "Acute pancreatitis is most often caused by gallstones, alcohol use, or hypertriglyceridemia, whereas malignancy is an uncommon association. We report a case of a 29-year-old woman with recurrent acute pancreatitis without a clearly dominant, identifiable cause. Although she reported intermittent heavy weekend alcohol use, recurrence after initial improvement, increasing lactate dehydrogenase (LDH), bilateral renal cortical lesions, and progressive retroperitoneal lymphadenopathy suggested a systemic process. Core biopsy of a retroperitoneal lymph node demonstrated a CD20-positive B-cell non-Hodgkin lymphoma with a Ki-67 proliferation index of up to 80%. Limited tissue and nondiagnostic flow cytometry prevented definitive subclassification; diffuse large B-cell lymphoma (DLBCL) remained in the differential diagnosis. One documented cycle of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) was administered during a subsequent hospitalization, with short-term symptomatic, pancreatic enzyme, and renal improvement. The patient was subsequently lost to follow-up. This case emphasizes the importance of considering lymphoproliferative disease when recurrent pancreatitis is accompanied by progressive systemic imaging abnormalities.",
  "abstract_shown": true,
  "affiliations": [
    "Internal Medicine, Palmetto General Hospital, Miami, USA.",
    "Internal Medicine, American University of the Caribbean School of Medicine, Miami, USA."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Rehan Sarfraz"
    },
    {
      "affs": [
        0
      ],
      "name": "Magnie L Ledesma Leon"
    },
    {
      "affs": [
        1
      ],
      "name": "Dunia Nabi"
    },
    {
      "affs": [
        0
      ],
      "name": "Laura Hernandez Carratala"
    },
    {
      "affs": [
        0
      ],
      "name": "Jennifer Fuller"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1z22546m7z078.bib",
  "cited_by": 0,
  "doi": "10.7759/cureus.116919",
  "fulltext_url": "https://europepmc.org/articles/PMC13695979",
  "id": "1z22546m7z078",
  "issns": [
    "2168-8184"
  ],
  "landing_url": "https://europepmc.org/article/MED/42928836",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2734|Lymphoma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7214360571",
  "pdf_url": "https://europepmc.org/articles/PMC13695979?pdf=render",
  "pmcid": "PMC13695979",
  "pmid": "42928836",
  "published": "2026-09-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1z22546m7z078.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42928836",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42928836"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2734|Lymphoma Diagnosis and Treatment",
      "subfield": "general"
    }
  ],
  "title": "CD20-Positive B-Cell Non-Hodgkin Lymphoma Associated With Recurrent Acute Pancreatitis, Bilateral Renal Lesions, and Retroperitoneal Lymphadenopathy.",
  "title_text": "CD20-Positive B-Cell Non-Hodgkin Lymphoma Associated With Recurrent Acute Pancreatitis, Bilateral Renal Lesions, and Retroperitoneal Lymphadenopathy.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/1z22546m7z078",
  "venue": "Cureus",
  "versions": []
}