{
  "abstract": "Background and Aims: N-glycans modulate glycoprotein structure and function and are altered during chronic inflammation. We sought to define the extent of serum and IgG N-glycan disruption in patients with decompensated liver cirrhosis from alcohol-related liver disease (ALD), primary sclerosing cholangitis (PSC), and ALD-related hepatocellular carcinoma (HCC). Finally, we aimed to examine whether serum and IgG glycosylation is associated with changes in Model for End-stage Liver Disease-Sodium (MELD-Na) scores, a clinical marker used to prioritise liver transplantation. Methods: Serum samples were obtained from patients with ALD (n = 17), PSC (n = 7), ALD-related HCC (n = 4), and healthy controls (n = 10). N-glycans were released, fluorescently labelled, and profiled by hydrophilic interaction ultra performance liquid chromatography (HILIC-UPLC). Chromatograms were integrated into 46 and 23 glycan peaks for serum and IgG respectively. These peaks and their associated glycosylation traits were statistically compared with healthy controls using age- and sex-adjusted linear regression models. Results: In serum, decompensated cirrhosis shows statistically significant shifts toward less complex, agalactosylated and asialylated biantennary glycans, accompanied by significant losses of highly branched, galactosylated and sialylated structures. IgG mirrored this pattern, which is characteristic of a pro-inflammatory signature, with increased agalactosylation and bisected glycan levels, along with reduced levels of digalactosylated and sialylated species. N-glycan profiles showed significant associations with MELD-Na scores, indicating that inflammatory processes in decompensated liver cirrhosis continue to reshape serum glycoproteins. Conclusion: Decompensated liver cirrhosis shows profound remodelling of serum and IgG N-glycans. These data establish a reference framework for terminal glycomic disruption in liver disease and highlight the potential value of incorporating glycosylation analysis into broader assessments of liver disease progression.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, Maynooth University, Maynooth, Co. Kildare, Ireland",
    "Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Co. Kildare, Ireland",
    "Department of Biology, Maynooth University, Maynooth, Co. Kildare, Ireland",
    "School of Medicine, University College Dublin, Belfield, Dublin, Ireland",
    "Department of Hepatopancreaticobiliary and Transplant Surgery, St. Vincent’s University Hospital, Elm Park, Dublin, Ireland",
    "Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Saint Stephen’s Green, Dublin, Ireland",
    "CÚRAM, Science Foundation Ireland Research Centre for Medical Devices, Biomedical Sciences, University of Galway, Co. Galway, Ireland"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
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        0
      ],
      "name": "Andreea Cislaru"
    },
    {
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        1
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      "name": "Emre Yagmur"
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    {
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        2
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      "name": "Catherine Bannon"
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    {
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        3
      ],
      "name": "Sinead Cremen"
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    {
      "affs": [
        4
      ],
      "name": "Tom K. Gallagher"
    },
    {
      "affs": [
        5
      ],
      "name": "Danilo Sarti"
    },
    {
      "affs": [
        6
      ],
      "name": "Mark W. Robinson"
    },
    {
      "name": "Róisín O’Flaherty"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1z492dymb2qgn.bib",
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  "doi": "10.1371/journal.pone.0357709",
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  "id": "1z492dymb2qgn",
  "issns": [
    "1932-6203"
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  "landing_url": "https://doi.org/10.1371/journal.pone.0357709",
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  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
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  "native_subjects": [
    [
      "openalex",
      "1312|Glycosylation and Glycoproteins Research"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Glycobiology/Glycoproteins"
    ],
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      "plos",
      "/Biology and life sciences/Biochemistry/Glycobiology/Glycosylation"
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      "plos",
      "/Biology and life sciences/Biochemistry/Proteins/Post-translational modification/Glycosylation"
    ],
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      "plos",
      "/Biology and life sciences/Nutrition/Diet/Alcohol consumption"
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      "/Medicine and health sciences/Gastroenterology and hepatology/Liver diseases"
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      "/Medicine and health sciences/Gastroenterology and hepatology/Liver diseases/Cirrhosis"
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      "/Medicine and health sciences/Medical conditions/Inflammatory diseases"
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      "/Medicine and health sciences/Nutrition/Diet/Alcohol consumption"
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      "/Medicine and health sciences/Pathology and laboratory medicine/Etiology"
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      "plos",
      "/Medicine and health sciences/Surgical and invasive medical procedures/Digestive system procedures/Liver transplantation"
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  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0357709&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-15",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/1z492dymb2qgn.ris",
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    {
      "first_seen": "2026-10-30T12:17:49Z",
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  "title": "Dysregulation of the serum and IgG N-glycome in decompensated cirrhosis and its association with Model for End-Stage Liver Disease-Sodium (MELD-Na)",
  "title_text": "Dysregulation of the serum and IgG N-glycome in decompensated cirrhosis and its association with Model for End-Stage Liver Disease-Sodium (MELD-Na)",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:49Z",
  "url": "https://research.draconitic.com/paper/1z492dymb2qgn",
  "venue": "PLOS One",
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