{
  "abstract": "Clindamycin is the alternative for intrapartum prophylaxis against group B Streptococcus in penicillin-allergic women, and whether it works depends on which lineages carry the resistance and on the mobile element that moves it. No Dominican group B Streptococcus genome has been closed. A Streptococcus agalactiae isolate from residual diagnostic material was sequenced twice on Oxford Nanopore, annotated, and screened against 83 genomes from a published Dominican maternal colonisation survey. The assembly is one circular chromosome of 2,066,859 bp with all seven rRNA operons resolved: ST347/CC19, serotype II, carrying erm(B), tet(O), mef(J) and msr(I). Two integrative conjugative elements were delimited: one of ~34 kb related to Tn5252 carrying erm(B) and tet(O), another of ~35 kb at a tRNA-Lys gene carrying mef(J) and msr(I). An eleven-gene class I lanthipeptide cluster lies 96 bp from the first element, on the same strand and with no annotated feature between them; its precursor encodes a 31-residue core identical to nisin P. The complete operon was found in 12 of the 83 genomes, 13 of 84 (15.5%) with the isolate. tet(O) was present in all 12 carriers and none of the 71 others (Fisher p = 1.03 x 10^-14), erm(B) in 12 of 12 against 3 of 71 (p = 4.70 x 10^-12). All eleven ST1 genomes lack both the operon and the nisin resistance protein; all 15 ST1010/IV genomes carry aac(6')-Ie/aph(2'')-Ia. Clindamycin resistance is therefore tightly associated with a lantibiotic-encoding element and contiguous with it in the one closed genome; in the drafts the relationship is statistical, and co-occurrence is not linkage. The ST1 absence predicts lineage-wide susceptibility, testable by deferred antagonism.",
  "abstract_shown": true,
  "affiliations": [
    "Instituto Especializado de Estudios Superiores Loyola"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "L. Garcia-Encarnacioin"
    },
    {
      "name": "D. S. De La Cruz-Caminero"
    },
    {
      "affs": [
        0
      ],
      "name": "H. B. Lopez-Chevalier"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1z68qsdjfnqva.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.29.762887",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.29.762887v1.full",
  "id": "1z68qsdjfnqva",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.29.762887v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "microbiology"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.29.762887v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/1z68qsdjfnqva.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T00:21:46Z",
      "native_id": "10.64898/2026.10.29.762887",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.29.762887v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:microbiology",
      "subfield": "microbiology"
    }
  ],
  "title": "A closed genome of Streptococcus agalactiae ST347/II reveals a composite integrative element coupling nisin P biosynthesis to erm(B) and tet(O) in Dominican group B Streptococcus",
  "title_text": "A closed genome of Streptococcus agalactiae ST347/II reveals a composite integrative element coupling nisin P biosynthesis to erm(B) and tet(O) in Dominican group B Streptococcus",
  "type": "preprint",
  "updated_at": "2026-11-06T00:21:35Z",
  "url": "https://research.draconitic.com/paper/1z68qsdjfnqva",
  "venue": "bioRxiv",
  "versions": []
}