{
  "abstract": "Background\n\nSuperior sagittal sinus thrombosis (SSST) is a rare but life-threatening form of cerebral venous thrombosis. Although several prothrombotic and autoimmune conditions are recognized risk factors, SSST occurring in patients with rheumatoid arthritis (RA) receiving tumor necrosis factor-alpha (TNF-α) inhibitor therapy remains exceptionally rare and poorly described in the literature.Case presentation\n\nWe present a 59-year-old Caucasian female with RA treated with infliximab who developed extensive superior sagittal sinus thrombosis with concurrent intracranial and subarachnoid hemorrhage. The patient was managed with anticoagulation, blood pressure control, and seizure prophylaxis, with subsequent clinical and radiologic improvement at one-month follow-up. Hypercoagulability evaluation was overall unrevealing, and no other clear provoking etiology was identified.Conclusions\n\nGiven the rarity of this presentation, we report this case to raise awareness of a possible association between cerebral venous thrombosis and TNF-α inhibitor therapy in patients with rheumatoid arthritis. This is especially important given the increasing and widespread use of biologic agents in the treatment of autoimmune diseases.",
  "abstract_shown": true,
  "affiliations": [
    "Internal Medicine Residency Program, UCF/HCA Healthcare Florida West Hospital, Pensacola, FL, USA.",
    "Department of Neurosurgery, HCA Healthcare Florida West Hospital, Pensacola, FL, USA.",
    "Department of Neurology, HCA Healthcare Florida West Hospital, Pensacola, FL, USA.",
    "Department of Critical Care, UCF/HCA Healthcare Florida West Hospital, Pensacola, FL, USA.",
    "Faculty of Pharmacy, German University in Cairo, Cairo, Egypt.",
    "Department of Critical Care, UCF/HCA Healthcare Florida West Hospital, Pensacola, FL, USA. Peter.fahim@hcahealthcare.com."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mohammad Rizwan Alam"
    },
    {
      "affs": [
        1
      ],
      "name": "Juan Corona-Ruiz"
    },
    {
      "affs": [
        2
      ],
      "name": "Joseph Cahill"
    },
    {
      "affs": [
        3
      ],
      "name": "William Goldsmith"
    },
    {
      "affs": [
        3
      ],
      "name": "Michael Sabra"
    },
    {
      "affs": [
        4
      ],
      "name": "Maro Issac"
    },
    {
      "affs": [
        5
      ],
      "name": "Peter Fahim"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1zf7rqfy72fva.bib",
  "cited_by": 0,
  "doi": "10.1186/s13256-026-06355-7",
  "fulltext_url": "https://europepmc.org/articles/PMC13685098",
  "id": "1zf7rqfy72fva",
  "issns": [
    "1752-1947"
  ],
  "landing_url": "https://europepmc.org/article/MED/42902419",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2728|Cerebral Venous Sinus Thrombosis"
    ]
  ],
  "openalex": "W7170537893",
  "pdf_url": "https://europepmc.org/articles/PMC13685098?pdf=render",
  "pmcid": "PMC13685098",
  "pmid": "42902419",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/1zf7rqfy72fva.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
      "native_id": "MED:42902419",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42902419"
    },
    {
      "first_seen": "2026-10-30T13:45:57Z",
      "native_id": "85e7d1f475c548d996be25f0feb7f161",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s13256-026-06355-7"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Cerebral Venous Sinus Thrombosis",
      "subfield": "neurology"
    }
  ],
  "title": "Superior sagittal sinus thrombosis with intracranial hemorrhage in a patient on infliximab: a case report.",
  "title_text": "Superior sagittal sinus thrombosis with intracranial hemorrhage in a patient on infliximab: a case report.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:57Z",
  "url": "https://research.draconitic.com/paper/1zf7rqfy72fva",
  "venue": "Journal of medical case reports",
  "versions": []
}