{
  "abstract": "Background: Recurrent pregnancy loss (RPL) is a multifactorial condition, with over 50% of cases remaining unexplained. The absence of therapeutic consensus raises questions regarding referral for assisted reproductive technology (ART).\n\nObjective: To evaluate live birth rates and predictors of success among women with RPL referred to a tertiary ART center.\n\nMethods: We conducted a retrospective cohort study. Women aged 18–42 years with ≥ 3 pregnancy losses before 14 weeks’ gestation, referred to the ART center of Amiens-Picardie University Hospital (2014–2022) were included. The primary outcome was achieving a live birth during follow-up. Independent predictors were identified using stepwise logistic regression.\n\nResults: Among the 85 women with RPL included (median age 29.6 [8.6] years), 49/85 (57.6%) had no underlying infertility issues, and 36/85 (42.3%) had associated infertility issues. Most women were nulliparous (50/85, 58.8%), and had a median of 3 [1] previous miscarriages. Overall, 64/85 (75.3%) achieved at least one live birth: 33/64 (52%) spontaneously and 31/64 (48%) via ART, with median times to conception of 13.6 [10.5] and 14.2 [10.6] months, respectively. ART use was more frequent among infertile women (≥1 IVF/ICSI cycle: 26/36, 72.2% vs. 17/49, 34.7%; p = 0.001), leading to a higher proportion of medically-assisted conceptions in this group (20/24, 83.3% vs. 11/40, 27.5%; p < 0.001). Diminished ovarian reserve and a higher number of previous miscarriages were independently associated with lower live birth rates (aOR 0.26 [0.08–0.89] and 0.76 [0.53–0.96], respectively).\n\nConclusion: Approximately three-quarters of women with RPL achieved a live birth, most after spontaneous conception. ART should be reserved for couples with confirmed infertility or when another underlying cause clearly justifies intervention.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s12978-026-02433-7.",
  "abstract_shown": true,
  "affiliations": [
    "Service de Gynécologie-Obstétrique, Centre Hospitalier Universitaire Amiens-Picardie, Université Picardie Jules Verne, Amiens, France",
    "Service de Médecine et biologie de la reproduction, Centres d’Étude et de Conservation des Œufs et du Sperme (CECOS), Centre Hospitalier Universitaire Amiens-Picardie, Université Picardie Jules Verne, Amiens, France",
    "Service de Médecine interne et Réseau d’Epidémiologie Clinique International Francophone (RECIF), Centre Hospitalier Universitaire Amiens-Picardie, Université Picardie Jules Verne, Amiens, France",
    "PERITOX-(UMR-I 01), UPJV/INERIS, UPJV, CURS, Chemin du Thil, Amiens, F-80025 France",
    "Equipe ECAMO, Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Paris, F-75004 France",
    "Centre Hospitalo-Universitaire Amiens-Picardie, Service de Médecine interne, Université Picardie Jules Verne, Réseau d’Epidémiologie Clinique International Francophone, Amiens, France"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sarah Derradj"
    },
    {
      "affs": [
        1
      ],
      "name": "Albane Vandecandelaere"
    },
    {
      "affs": [
        2
      ],
      "name": "Pierre Loiseau"
    },
    {
      "affs": [
        1
      ],
      "name": "Dorian Bosquet"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Rosalie Cabry"
    },
    {
      "affs": [
        2,
        4,
        5
      ],
      "name": "Amandine Dernoncourt",
      "orcid": "0000-0003-0829-8764"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1zgym1dtznz4e.bib",
  "cited_by": 0,
  "doi": "10.1186/s12978-026-02433-7",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13733088/",
  "id": "1zgym1dtznz4e",
  "issns": [
    "1742-4755"
  ],
  "landing_url": "https://doi.org/10.1186/s12978-026-02433-7",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2403|Reproductive System and Pregnancy"
    ]
  ],
  "openalex": "W7201878404",
  "pdf_url": null,
  "pmcid": "PMC13733088",
  "pmid": "42983561",
  "published": "2026-08-08",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/1zgym1dtznz4e.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:22:57Z",
      "native_id": "PMC13733088",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12978-026-02433-7"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Reproductive System and Pregnancy",
      "subfield": "immunology"
    }
  ],
  "title": "Chance of live birth in women with recurrent pregnancy loss referred to a French assisted reproductive technology center",
  "title_text": "Chance of live birth in women with recurrent pregnancy loss referred to a French assisted reproductive technology center",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:57Z",
  "url": "https://research.draconitic.com/paper/1zgym1dtznz4e",
  "venue": "Reproductive Health",
  "versions": []
}