{
  "abstract": "Purpose: This scoping review aimed to map the available evidence on the safety and efficacy of anti-inflammatory dietary supplements used during pregnancy, assessing maternal and fetal outcomes. Methods: A systematic literature search was conducted in PubMed, Scopus, and Web of Science (January 2016–June 2026), following PRISMA-ScR guidelines. The protocol was prospectively registered on the Open Science Framework (10.17605/osf.io/4kmv9). Eligible studies included human clinical trials and observational studies evaluating anti-inflammatory dietary supplements in pregnant women. Results: Eighty unique studies (96 publications) from 28 countries were included, of which 63 (78.8%) were randomized clinical trials. Thirteen supplement categories were identified. Vitamin D (n = 23) and omega-3 fatty acids (n = 17) accounted for nearly half of all studies; probiotics (n = 11) formed the third-largest category. For these three supplements, most studies reported changes in inflammatory and glycemic markers, primarily in gestational diabetes mellitus and high-risk populations, but adverse events were collected in a minority of studies, so tolerability is documented rather than established. Evidence for zinc, magnesium, and alpha-lipoic acid was limited. Curcumin, chlorella, vitamin E, epigallocatechin-3-gallate (EGCG), resveratrol, and ginger were each supported by only one or two studies. Supplementation was initiated in the first trimester in 19 studies (23.8%), and neonatal safety outcomes were reported infrequently. Conclusions: Evidence on anti-inflammatory dietary supplements in pregnancy is concentrated in a few compounds, in a small number of countries, and in biochemical outcomes measured in selected populations. Tolerability was evaluated in only a small number of studies, which limits its use as an indicator of safety. The map highlights the scarcity of controlled studies with prespecified harm outcomes, of first-trimester initiation, and of infant follow-up beyond the first months of life.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pharmacology, Physiology, Pathophysiology, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania",
    "HIVE Health Innovation Center, Babeș-Bolyai University, 400095 Cluj-Napoca, Romania",
    "Department of Neurosciences—Psychiatry and Pediatric Psychiatry, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Anamaria Apan",
      "orcid": "0000-0002-3749-7589"
    },
    {
      "affs": [
        0
      ],
      "name": "Cristina Pop",
      "orcid": "0000-0002-9088-8589"
    },
    {
      "affs": [
        0
      ],
      "name": "Irina Iaru"
    },
    {
      "affs": [
        0
      ],
      "name": "Oliviu Voștinaru",
      "orcid": "0000-0003-4505-4005"
    },
    {
      "affs": [
        1
      ],
      "name": "Răzvan Mircea Cherecheș"
    },
    {
      "affs": [
        2
      ],
      "name": "Maria Bonea",
      "orcid": "0000-0003-1853-4425"
    },
    {
      "affs": [
        0
      ],
      "name": "Cristina Mogoșan",
      "orcid": "0000-0002-6854-2194"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1zhwyt30spk2f.bib",
  "cited_by": 0,
  "doi": "10.3390/nu18213627",
  "fulltext_url": null,
  "id": "1zhwyt30spk2f",
  "issns": [
    "2072-6643"
  ],
  "landing_url": "https://www.mdpi.com/2072-6643/18/21/3627",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-31",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/1zhwyt30spk2f.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T00:26:35Z",
      "native_id": "10.3390/nu18213627",
      "source": "crossref",
      "url": "https://www.mdpi.com/2072-6643/18/21/3627"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2072-6643",
      "subfield": "nutrition"
    }
  ],
  "title": "Anti-Inflammatory Dietary Supplements in Pregnancy: A Scoping Review",
  "title_text": "Anti-Inflammatory Dietary Supplements in Pregnancy: A Scoping Review",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T00:21:09Z",
  "url": "https://research.draconitic.com/paper/1zhwyt30spk2f",
  "venue": "Nutrients",
  "versions": []
}