{
  "abstract": "Objectives: This study elucidated the association between acute myocardial infarction (AMI) and Neogenin-1 (NEO-1) using proteomics to identify NEO-1 as a promising circulating biomarker for AMI risk prediction.\n\nMethods: A total of 107 participants were included in the analysis, comprising 45 control subjects without coronary heart disease (non-coronary heart disease [NCHD]; as a control group) and 62 patients with AMI. Furthermore, mRNA levels were elucidated via RT-qPCR, whereas the protein content was measured using enzyme-linked immunosorbent assay (ELISA). Lastly, the acquired data were elucidated and compared.\n\nResults: The data showed that relative to the NCHD group, the AMI group’s NEO-1 mRNA level in peripheral blood (PB) mononuclear cells was 1.47 times higher (p<0.05), whereas NEO-1 protein levels were 1.50 times higher (p<0.05). Furthermore, in AMI patients, the expression of NEO-1 was not related to smoking, total cholesterol, alcohol consumption, triglycerides, age, high-density lipoprotein cholesterol, hypertension, or platelets. Moreover, Logistic regression assessment revealed that AMI was associated with elevated NEO-1 expression and enhanced fasting blood glucose.\n\nConclusions: This study revealed that relative to the NCHD patients, AMI patients had elevated PB NEO-1 expression, which was an independent risk factor for AMI. These findings indicate that NEO-1 expression is a potential bio-index for AMI.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China",
    "Department of Endocrinology, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zhaolin Yang"
    },
    {
      "affs": [
        1
      ],
      "name": "Heyu Meng",
      "orcid": "0000-0003-2811-2330"
    },
    {
      "affs": [
        0
      ],
      "name": "Jianjun Ruan"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhiqi Yao"
    },
    {
      "affs": [
        0
      ],
      "name": "Fanbo Meng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1zst05w2h5bbn.bib",
  "cited_by": 0,
  "doi": "10.1515/med-2026-1558",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13718989/?tool=EBI",
  "id": "1zst05w2h5bbn",
  "issns": [
    "1911-2092",
    "2391-5463"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13718989",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2705|Acute Myocardial Infarction Research"
    ]
  ],
  "openalex": "W7224459545",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13718989/pdf/?tool=EBI",
  "pmcid": "PMC13718989",
  "pmid": "42960320",
  "published": "2026-10-30",
  "publisher": "De Gruyter",
  "ris": "https://research.draconitic.com/paper/1zst05w2h5bbn.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:37Z",
      "native_id": "PMC:PMC13718989",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13718989"
    },
    {
      "first_seen": "2026-11-02T12:22:54Z",
      "native_id": "PMC13718989",
      "source": "pmc",
      "url": "https://doi.org/10.1515/med-2026-1558"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Acute Myocardial Infarction Research",
      "subfield": "cardiovascular"
    }
  ],
  "title": "The NEO-1 gene may serve as a potential biomarker for predicting acute myocardial infarction",
  "title_text": "The NEO-1 gene may serve as a potential biomarker for predicting acute myocardial infarction",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:54Z",
  "url": "https://research.draconitic.com/paper/1zst05w2h5bbn",
  "venue": "Open Medicine",
  "versions": []
}