{
  "abstract": "The rapidly developing research field of brain-body neuroscience faces methodological challenges, as analysts continue to develop new analysis strategies in the absence of established best practices. This quest for valid methods is further complicated by the (naturally) circular data involved in the study of phase-locked effects, e.g., in respiration-brain coupling. Various available approaches for phase extraction, constructing adequate surrogate data for statistical comparison, and accounting for the circularity of respiratory data lead to poor cross-study generalisability of results. Interpretation of effects is particularly affected by the problem of multiple comparisons in phase-related inferential statistics. In this tutorial, we propose a robust pipeline for respiration phase-related analyses based on a novel circular extension of cluster-based permutation testing. We highlight and offer guidance on critical parameters in the analysis, systematically compare various approaches being used in the field today, and provide open-access software code for flexible use and future development of our proposed pipeline. Author summary: Conventional best-practice statistical approaches have so far been difficult to implement in cases where the underlying data are circular, for example in the analysis of phase data. Such analyses are common in the up-and-coming research field of brain-body neuroscience, which poses significant challenges. In this tutorial, we use the case of respiration to propose a robust pipeline for phase-related analyses based on a novel circular extension of cluster-based permutation testing. We highlight and offer guidance on critical parameters in the analysis, systematically compare various approaches being used in the field today, and provide open-access software code for flexible use and future development of our proposed pipeline.",
  "abstract_shown": true,
  "affiliations": [
    "Institute for Biomagnetism and Biosignal Analysis, University of Münster, Münster, Germany",
    "Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, Münster, Germany",
    "Department of Linguistics, Cognitive Science and Semiotics, Aarhus University, Aarhus, Denmark",
    "Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark"
  ],
  "article_type": "Methods",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Teresa Berther"
    },
    {
      "affs": [
        1
      ],
      "name": "Elio Balestrieri"
    },
    {
      "affs": [
        2
      ],
      "name": "Martina Saltafossi"
    },
    {
      "affs": [
        3
      ],
      "name": "Laura Bock Paulsen"
    },
    {
      "name": "Lau M. Andersen"
    },
    {
      "name": "Daniel S. Kluger"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/1zvmq3p4rbw60.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pcbi.1014672",
  "fulltext_url": "https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1014672",
  "id": "1zvmq3p4rbw60",
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  "landing_url": "https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1014672",
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  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2805|Neural dynamics and brain function"
    ],
    [
      "plos",
      "/Biology and life sciences/Physiology/Respiratory physiology"
    ],
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      "/Biology and life sciences/Psychology/Behavior"
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      "/Physical sciences/Mathematics/Statistics/Statistical methods/Autocorrelation"
    ],
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      "plos",
      "/Research and analysis methods/Bioassays and physiological analysis/Respiratory analysis"
    ],
    [
      "plos",
      "/Research and analysis methods/Mathematical and statistical techniques/Statistical methods/Autocorrelation"
    ],
    [
      "plos",
      "/Research and analysis methods/Research assessment/Research errors"
    ],
    [
      "plos",
      "/Social sciences/Psychology/Behavior"
    ]
  ],
  "openalex": "W4416696403",
  "pdf_url": "https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1014672&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-03",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/1zvmq3p4rbw60.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:56Z",
      "native_id": "10.1371/journal.pcbi.1014672",
      "source": "plos",
      "url": "https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1014672"
    }
  ],
  "subjects": [
    {
      "field": "mathematics",
      "origin": "plos:statistics",
      "subfield": "statistics"
    }
  ],
  "title": "Robust circular cluster-based statistics for respiration-brain coupling",
  "title_text": "Robust circular cluster-based statistics for respiration-brain coupling",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:56Z",
  "url": "https://research.draconitic.com/paper/1zvmq3p4rbw60",
  "venue": "PLOS Computational Biology",
  "versions": []
}