{
  "abstract": "Background: Head-to-head comparisons of contemporary drug-eluting stents (DES) in patients with acute myocardial infarction (AMI) remain limited. We sought to compare the long-term clinical outcomes of four widely used DES platforms: Orsiro, Xience, Synergy, and Resolute.\n\nMethods: From the nationwide prospective Korea acute myocardial infarction registry-V, we identified 9284 patients with AMI undergoing percutaneous coronary intervention with one of the four study devices (Orsiro, n = 1634; Xience, n = 2576; Synergy, n = 2811; Resolute, n = 2263). The primary endpoint was target lesion revascularization (TLR). Inverse probability of treatment weighting was performed to adjust for baseline differences.\n\nResults: During a median follow-up of 723 days, the cumulative incidence of TLR differed significantly among groups. In IPTW-adjusted analyses, compared with the Orsiro group (reference), the risk of TLR was significantly higher in the Synergy [hazard ratio: 2.30; 95% confidence interval (CI): 1.20–4.41, P = 0.013] and Resolute groups (hazard ratio: 2.30, 95% CI: 1.18–4.47, P = 0.014). The Xience group showed a comparable risk of TLR to Orsiro (hazard ratio: 1.40, 95% CI: 0.69–2.82, P = 0.346). Target vessel revascularization followed a similar pattern, favoring Orsiro. However, there were no significant differences in composite major adverse cardiovascular events or all-cause mortality among the four groups.\n\nConclusion: In this large-scale, real-world AMI cohort, the ultrathin-strut, biodegradable-polymer Orsiro stent was associated with a lower risk of repeat revascularization compared with the Synergy and Resolute stents. Xience demonstrated comparable outcomes to Orsiro. Stent selection remains a crucial determinant of vessel-level outcomes in patients with AMI.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Cardiology, Department of Internal Medicine, Chungnam National University School of Medicine, Chungnam National University Hospital, Daejeon",
    "Division of Cardiology, Department of Internal Medicine, Chungnam National University School of Medicine, Chungnam National University Sejong Hospital, Sejong",
    "Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju",
    "Department of Internal Medicine and Cardiovascular Center, Daejeon Eulji University Hospital, Daejeon",
    "Department of Internal Medicine, Gyeongsang National University School of Medicine, Gyeongsang National University Hospital, Jinju",
    "Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hyun Woong Park"
    },
    {
      "affs": [
        1
      ],
      "name": "Yong Kyun Kim"
    },
    {
      "affs": [
        0
      ],
      "name": "Seok-Woo Seong"
    },
    {
      "affs": [
        0
      ],
      "name": "Jae-Hwan Lee"
    },
    {
      "affs": [
        0
      ],
      "name": "Mi Joo Kim"
    },
    {
      "affs": [
        0
      ],
      "name": "Pil Sang Song"
    },
    {
      "affs": [
        0
      ],
      "name": "Seon-Ah Jin"
    },
    {
      "affs": [
        0
      ],
      "name": "Kye Taek Ahn"
    },
    {
      "affs": [
        2
      ],
      "name": "Youngkeun Ahn"
    },
    {
      "affs": [
        3
      ],
      "name": "Sang Hyun Park"
    },
    {
      "affs": [
        4
      ],
      "name": "Jin-Yong Hwang"
    },
    {
      "affs": [
        5
      ],
      "name": "Chang-Hwan Yoon"
    },
    {
      "affs": [
        0
      ],
      "name": "Jin-Ok Jeong"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/201m72kf0wck2.bib",
  "cited_by": 0,
  "doi": "10.1097/mca.0000000000001659",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13716299/",
  "id": "201m72kf0wck2",
  "issns": [
    "0954-6928",
    "1473-5830"
  ],
  "landing_url": "https://doi.org/10.1097/mca.0000000000001659",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2746|Coronary Interventions and Diagnostics"
    ]
  ],
  "openalex": "W7165123859",
  "pdf_url": null,
  "pmcid": "PMC13716299",
  "pmid": "42313105",
  "published": "2026-06-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/201m72kf0wck2.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:23:20Z",
      "native_id": "PMC13716299",
      "source": "pmc",
      "url": "https://doi.org/10.1097/mca.0000000000001659"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Coronary Interventions and Diagnostics",
      "subfield": "surgery"
    }
  ],
  "title": "Comparative effectiveness of Orsiro, Xience, Synergy, and Resolute stent in patients with acute myocardial infarction undergoing percutaneous coronary intervention: a nationwide registry study",
  "title_text": "Comparative effectiveness of Orsiro, Xience, Synergy, and Resolute stent in patients with acute myocardial infarction undergoing percutaneous coronary intervention: a nationwide registry study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:23:20Z",
  "url": "https://research.draconitic.com/paper/201m72kf0wck2",
  "venue": "Coronary Artery Disease",
  "versions": []
}