{
  "abstract": "Simulated microgravity provides a controlled perturbation for testing how loss of mechanical load affects human tissues. After 24 hours in rotating-wall vessels, neural, cardiac and tonsil organoids developed tissue-specific transcriptional responses that overlapped published spaceflight datasets, accompanied by higher transcriptomic-age estimates in neural and cardiac models, altered cardiac-organoid contraction dynamics and modified tonsil-organoid antiviral gene-expression signatures. These findings establish a multi-organoid framework for studying acute responses to gravitational unloading.",
  "abstract_shown": true,
  "affiliations": [
    "Buck Institute"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "name": "W.-C. Mu"
    },
    {
      "name": "J. Baechle"
    },
    {
      "name": "K. Schneider"
    },
    {
      "name": "M. Fuentealba"
    },
    {
      "name": "F. Wu"
    },
    {
      "name": "M. Manwaring-Mueller"
    },
    {
      "name": "N. Bracey"
    },
    {
      "name": "A. Chebykin"
    },
    {
      "name": "A. Saini"
    },
    {
      "name": "J. Park"
    },
    {
      "name": "J. Kim"
    },
    {
      "name": "D. A. Winer"
    },
    {
      "name": "A. I. Gale"
    },
    {
      "name": "C. Mason"
    },
    {
      "name": "M. M. Davis"
    },
    {
      "affs": [
        0
      ],
      "name": "D. Furman"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/20ye8v7qr1w0c.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.30.755771",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.30.755771v1.full",
  "id": "20ye8v7qr1w0c",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.30.755771v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "molecular biology"
    ],
    [
      "openalex",
      "2737|Spaceflight effects on biology"
    ]
  ],
  "openalex": "W7215030154",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.30.755771v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/20ye8v7qr1w0c.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:25:44Z",
      "native_id": "10.64898/2026.09.30.755771",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.30.755771v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "biorxiv:molecular biology",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Simulated microgravity induces aging phenotypes in human organoids",
  "title_text": "Simulated microgravity induces aging phenotypes in human organoids",
  "type": "preprint",
  "updated_at": "2026-10-30T12:25:44Z",
  "url": "https://research.draconitic.com/paper/20ye8v7qr1w0c",
  "venue": "bioRxiv",
  "versions": []
}