{
  "abstract": "Chronic wound healing is often impaired in conditions such as metabolic syndrome, requiring effective therapeutic interventions to promote tissue regeneration and repair. In this study, we evaluated the wound healing potential of petroleum jelly (P Jelly)-based bioactive glass ointments (PBGCu) with varying copper concentrations (0, 1, and 3 wt%) in both in vitro and in vivo models of wound healing. PBGCu formulations demonstrated high biocompatibility with human dermal fibroblasts (HDF) and human umbilical vein endothelial cells (HUVEC). Additionally, PBGCu ointments exhibited strong antibacterial activity against Staphylococcus aureus , suggesting their utility for the care of chronic wounds. In both metabolic syndrome mouse and pig models, PBGCu3-treated wounds showed significantly faster wound closure, enhanced epithelial regeneration, and increased dermal thickness compared to saline and P Jelly controls. Histological analysis also revealed 50% increased vascularization (p < 0.0001) and a 90% reduction in scar formation (p < 0.0001) in PBGCu3-treated wounds. These findings show that PBGCu formulations, especially at 3 wt% copper concentration, significantly improve wound healing by promoting epithelial regeneration, dermal tissue formation, and vascularization, while also offering antibacterial protection. The sustained Cu 2+ ions release from PBGCu ointments provides long-term support for tissue regeneration, positioning this ointment composition as a promising therapeutic tool for chronic wound management. Future studies will focus on elucidating the underlying mechanisms and evaluating the therapeutic efficacy of PBGCu formulations in infected wounds.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, 60208, USA; Department of Chemistry and Materials Science, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu, 215123, China",
    "Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA",
    "Joint Department of Biomedical Engineering, NC State University, Raleigh, NC, 27606, USA",
    "Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA; Querrey Simpson Institute for Regenerative Engineering at Northwestern University, Chicago, IL, 60611, USA; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, 60208, USA",
    "Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA; Querrey Simpson Institute for Regenerative Engineering at Northwestern University, Chicago, IL, 60611, USA; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, 60208, USA; Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
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        0
      ],
      "name": "Huifeng Wang"
    },
    {
      "affs": [
        1
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      "name": "Ophelia Tong"
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    {
      "affs": [
        1
      ],
      "name": "Youssef Ibrahim"
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    {
      "affs": [
        2
      ],
      "name": "Muskan Aslam"
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    {
      "affs": [
        1
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      "name": "Yugang Liu"
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    {
      "affs": [
        1
      ],
      "name": "Chongwen Duan"
    },
    {
      "name": "Ruyue Luo"
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    {
      "affs": [
        1
      ],
      "name": "Angel Guo"
    },
    {
      "affs": [
        3
      ],
      "name": "Mirae Kim"
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    {
      "affs": [
        1
      ],
      "name": "Emma Vinokour"
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    {
      "affs": [
        1
      ],
      "name": "Andrew Kang"
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    {
      "affs": [
        1
      ],
      "name": "Pritika Jakka"
    },
    {
      "affs": [
        4
      ],
      "name": "Bin Jiang"
    },
    {
      "name": "Guillermo A. Ameer"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/20zdmwgs3nx3e.bib",
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  "doi": "10.1016/j.mtbio.2026.103769",
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  "landing_url": "https://doi.org/10.1016/j.mtbio.2026.103769",
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  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13721936/pdf/?tool=EBI",
  "pmcid": "PMC13721936",
  "pmid": "42965154",
  "published": "2026-10-20",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/20zdmwgs3nx3e.ris",
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2742|Wound Healing and Treatments",
      "subfield": "general"
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  ],
  "title": "A pro-regenerative petroleum jelly-based, copper-doped bioactive glass ointment for impaired wound healing in metabolic syndrome",
  "title_text": "A pro-regenerative petroleum jelly-based, copper-doped bioactive glass ointment for impaired wound healing in metabolic syndrome",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:32Z",
  "url": "https://research.draconitic.com/paper/20zdmwgs3nx3e",
  "venue": "Materials Today Bio",
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}