{
  "abstract": "Controlling the delivery of chemotherapy to the tumor site is a long-standing goal of the medical field, as it could not only enhance the anticancer activity of the treatment but also reduce damage to the rest of the body. The emergence of bioorthogonal catalysis as a strategy capable of mediating continuous drug production in a nonenzymatic fashion has created the opportunity to develop so-called “bioorthogonal therapies,” which aim to generate the anticancer agents inside the tumors. Herein, we describe a novel class of supramolecular materials comprising ultrathin palladium nanosheets and fluorenylmethoxycarbonyl-diphenylalanine that self-assemble in water to form injectable, self-healing, biocompatible catalytic gels that convert inactive prodyes and prodrugs into active small molecules. The relatively weak physicochemical cross-links generated by the hybrid metal-peptide fibers facilitate the flow of the gel under mild shear stress (shear-thinning), thereby enabling precise intratumoral injections in vivo and localized prodrug activation. The strategy was validated in an aggressive pancreatic cancer xenograft model in mice, setting out a new direction for the field of bioorthogonal therapies.",
  "abstract_shown": true,
  "affiliations": [
    "Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, EH4 2XU Edinburgh, U.K.",
    "Nanoscopy-UGR Laboratory, Faculty of Pharmacy, University of Granada, E-18011 Granada, Spain",
    "Unidad de Excelencia Química Aplicada a Biomedicina y Medioambiente (UEQ), Universidad de Granada, E-18071 Granada, Spain",
    "Instituto de Nanociencia y Materiales de Aragon (INMA), CSIC−University of Zaragoza, E-50009 Zaragoza, Spain",
    "Department of Chemical and Environmental Engineering Universidad de Zaragoza Campus Rio Ebro, E-50018 Zaragoza, Spain",
    "Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-28029 Madrid, Spain",
    "Instituto de Investigación Sanitaria (IIS) de Aragón, Avenida San Juan Bosco, 13, 50009 Zaragoza, Spain",
    "POLYMAT and Department of Applied Chemistry, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizabal 3, E-20018 Donostia-San Sebastián, Spain",
    "Department of Applied Physics and Research Unit “Modeling Nature” (MNat), University of Granada, Avenida de Fuentenueva, E-18071 Granada, Spain",
    "Instituto de Investigación Biosanitaria ibs.GRANADA, Av. de Madrid, 15, E-18016 Granada, Spain",
    "Laboratorio de Microscopías Avanzadas, Universidad de Zaragoza, E-50018 Zaragoza, Spain",
    "Department of Organic Chemistry, University of Granada, Avenida de Fuentenueva, E-18071 Granada, Spain"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Rafael Contreras-Montoya",
      "orcid": "0000-0002-0766-004X"
    },
    {
      "affs": [
        3,
        4,
        5,
        6
      ],
      "name": "Maria Sancho-Albero",
      "orcid": "0000-0001-8762-5457"
    },
    {
      "affs": [
        0
      ],
      "name": "Catherine Adam"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Federico Movilla",
      "orcid": "0000-0003-0800-6282"
    },
    {
      "affs": [
        7
      ],
      "name": "Mari C. Mañas-Torres"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "Modesto T. López-López",
      "orcid": "0000-0002-9068-7795"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Angel Orte",
      "orcid": "0000-0003-1905-4183"
    },
    {
      "affs": [
        3,
        4,
        5,
        6,
        10
      ],
      "name": "Victor Sebastian",
      "orcid": "0000-0002-6873-5244"
    },
    {
      "affs": [
        2,
        9,
        11
      ],
      "name": "Luis Álvarez de Cienfuegos",
      "orcid": "0000-0001-8910-4241"
    },
    {
      "affs": [
        0
      ],
      "name": "Asier Unciti-Broceta",
      "orcid": "0000-0003-1029-2855"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/211h7ybfxbd8j.bib",
  "cited_by": 0,
  "doi": "10.1021/jacs.6c19546",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13741829/",
  "id": "211h7ybfxbd8j",
  "issns": [
    "0002-7863",
    "1520-5126"
  ],
  "landing_url": "https://doi.org/10.1021/jacs.6c19546",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2502|Supramolecular Self-Assembly in Materials"
    ]
  ],
  "openalex": "W7223170028",
  "pdf_url": null,
  "pmcid": "PMC13741829",
  "pmid": "42984068",
  "published": "2026-10-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/211h7ybfxbd8j.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T12:22:48Z",
      "native_id": "PMC13741829",
      "source": "pmc",
      "url": "https://doi.org/10.1021/jacs.6c19546"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Supramolecular Self-Assembly in Materials",
      "subfield": "materials-polymers"
    }
  ],
  "title": "MetallopeptiGELs: Injectable Short-Peptide Supramolecular Hydrogels Self-Assembled by Pd Nanosheets for Bioorthogonal Therapy",
  "title_text": "MetallopeptiGELs: Injectable Short-Peptide Supramolecular Hydrogels Self-Assembled by Pd Nanosheets for Bioorthogonal Therapy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T12:22:48Z",
  "url": "https://research.draconitic.com/paper/211h7ybfxbd8j",
  "venue": "Journal of the American Chemical Society",
  "versions": []
}