{
  "abstract": "Tetrabromobisphenol A bis(allyl ether) (TBBPA-BAE) is an emerging aquatic contaminant, yet its developmental toxicity, particularly its stage-dependent skeletal effects, remains poorly understood. Zebrafish embryos and larvae were continuously exposed to nominal concentrations of 0.2, 2, 20, or 200 µg/L TBBPA-BAE (BAE0.2, BAE2, BAE20, and BAE200) through 14 days post-fertilization (dpf), with the lowest concentration approximating the upper end of reported environmental concentrations. Exposure transiently delayed hatching and altered heart rate and locomotion. At 5 dpf, H₂O₂ increased at all concentrations, whereas superoxide-scavenging capacity, catalase, and total superoxide dismutase showed distinct concentration-dependent responses, indicating disrupted redox homeostasis rather than uniform antioxidant activation. Selective craniofacial cartilage changes were also observed. At 14 dpf, craniofacial mineralization changed non-monotonically, increasing in BAE2 and BAE20 but decreasing in BAE200. Increased cranial TRAP staining together with osteoclast-related transcriptional changes indicated altered osteoclast-associated remodeling, while RANKL-RANK-OPG-related transcripts showed non-coordinated regulation. BAE20 produced the largest 5 dpf transcriptomic response, with changes involving redox response, extracellular matrix regulation, and osteoclast-related processes. Overall, TBBPA-BAE induced stage-dependent, non-monotonic developmental responses characterized by early redox disturbance and later osteoclast-associated skeletal alterations.",
  "abstract_shown": true,
  "affiliations": [
    "School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.",
    "School of Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China.",
    "Key Laboratory of Marine Ecological Conservation and Restoration, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lele Fu",
      "orcid": "0009-0006-5534-0194"
    },
    {
      "affs": [
        1
      ],
      "name": "Hai Xu",
      "orcid": "0000-0001-6549-1486"
    },
    {
      "affs": [
        0
      ],
      "name": "Qing Wei",
      "orcid": "0009-0001-9246-6566"
    },
    {
      "affs": [
        0
      ],
      "name": "Yungu Zheng",
      "orcid": "0000-0003-1499-3325"
    },
    {
      "affs": [
        2
      ],
      "name": "Ling Cai",
      "orcid": "0000-0001-6198-7978"
    },
    {
      "affs": [
        0
      ],
      "name": "Ming Yang",
      "orcid": "0000-0001-6417-4235"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/211mz9804hrq4.bib",
  "cited_by": 0,
  "doi": "10.3390/antiox15101242",
  "fulltext_url": "https://europepmc.org/articles/PMC13700801",
  "id": "211mz9804hrq4",
  "issns": [
    "2076-3921"
  ],
  "landing_url": "https://europepmc.org/article/MED/42939818",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2307|Environmental Toxicology and Ecotoxicology"
    ]
  ],
  "openalex": "W7214591095",
  "pdf_url": "https://europepmc.org/articles/PMC13700801?pdf=render",
  "pmcid": "PMC13700801",
  "pmid": "42939818",
  "published": "2026-09-26",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/211mz9804hrq4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42939818",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42939818"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2307|Environmental Toxicology and Ecotoxicology",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Developmental Toxicity of Tetrabromobisphenol A Bis(allyl ether) in Zebrafish: Redox Disturbance and Osteoclast-Associated Skeletal Responses.",
  "title_text": "Developmental Toxicity of Tetrabromobisphenol A Bis(allyl ether) in Zebrafish: Redox Disturbance and Osteoclast-Associated Skeletal Responses.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:24Z",
  "url": "https://research.draconitic.com/paper/211mz9804hrq4",
  "venue": "Antioxidants (Basel, Switzerland)",
  "versions": []
}